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A Systematic Review and Meta-Analysis of Conditioned Pain Modulation in Children and Young People with Chronic Pain.
Children (Basel)
November 2024
Pain Research Laboratory, School of Psychology, University of Southampton, Highfield, Southampton SO17 1BJ, UK.
Background/objectives: Conditioned pain modulation (CPM) is a psychophysical experimental measure of the endogenous pain inhibitory pathway in humans, wherein one pain stimulus (the conditioning stimulus) is used to inhibit an individual's perception of a second painful (test) stimulus. Research provides evidence of impaired endogenous inhibitory pain responses in adults with chronic pain. CPM is now increasingly applied in paediatric research and clinical practice.
View Article and Find Full Text PDFHibiscus schizopetalus boosts wound healing via restoring redox balance and hindering inflammatory responses in rats: Insights on metabolome profiling and molecular docking.
Arch Pharm (Weinheim)
November 2024
Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Hibiscus species (Malvaceae) possess a plethora of appealing pharmacological activities with an extended history of customary use in diverse medical conditions. The present study aimed at comparing the metabolomic analyses of three Hibiscus species native to Egypt, namely H. tiliaceus, H.
View Article and Find Full Text PDFIntervention studies with group design targeting expressive phonology for children with developmental speech and language disorder: A systematic review and meta-analysis.
Int J Lang Commun Disord
November 2024
Department of Logopedics, School of Humanities, University of Eastern Finland, Kuopio, Finland.
Background: Phonological difficulties are prevalent in children with speech and/or language disorders and may hamper their later language outcomes and academic achievements. These children often form a significant proportion of speech and language therapists' caseloads. There is a shortage of information on evidence-based interventions for improving phonological skills in children and adolescents with speech and language disorder.
View Article and Find Full Text PDFAssessing the causal association of pregnancy complications with diabetes and cardiovascular disease.
Front Endocrinol (Lausanne)
June 2024
Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Background: To the best of our knowledge, numerous observational studies have linked pregnancy complications to increased risks of diabetes and cardiovascular disease (CVD), causal evidence remains lacking. Our aim was to estimate the association of adverse pregnancy outcomes with diabetes and cardiovascular diseases.
Methods: A two-sample Mendelian randomization (MR) analysis was employed, which is not subject to potential reverse causality.
A Systematic Review of Conservatively Managed Isolated Extra-Articular Proximal Phalanx Finger Fractures in Adults.
JPRAS Open
September 2024
Plastic and Reconstructive Surgery Department, Austin Health, 145 Studley Rd, Heidelberg, VIC 3084, Australia.
Study Design: Systematic review.
Background: Proximal phalangeal fractures of the hand are challenging to treat, and significantly impact hand function and quality of life if poorly managed.
Purpose: A systematic review to determine the efficacy of conservatively managed extra-articular proximal phalanx fractures to optimise recovery and prevent the need for surgical intervention and its associated risks.
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