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A high-performance extracellular field potential analyzer for iPSC-derived cardiomyocytes.
Sci Rep
March 2025
Department of Medicine, Vanderbilt University School of Medicine, 2215 Garland Ave, Nashville, TN, 37232, USA.
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have emerged as a pivotal model for research. Specialized devices can generate Extracellular Field Potential (EFP) measurements from these cells, analogous to the ventricular complex of the electrocardiogram. However, electrophysiological analysis can be complex and requires specialized expertise, posing a barrier to broader adoption in non-specialized labs.
View Article and Find Full Text PDFImplantable Cardioverter-Defibrillator Therapy in Brugada Syndrome: A 30-Year Single-Center Experience.
JACC Clin Electrophysiol
February 2025
Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, European Reference Networks, Guard-Heart, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel, Brussels, Belgium. Electronic address:
Background: Brugada syndrome (BrS) continues to pose clinical challenges, despite 3 decades of dedicated research and therapeutic advancements. The pivotal role of implantable cardioverter-defibrillator (ICD) therapy in safeguarding high-risk BrS patients from sudden cardiac death due to ventricular arrhythmias is undeniable. However, the debate on risk stratification and the use of ICDs for primary prevention remains ongoing.
View Article and Find Full Text PDFThe Association of Electrical Delay on Hemodynamic Response With Cardiac Resynchronization Therapy.
JACC Clin Electrophysiol
February 2025
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA. Electronic address:
Background: The effect of electrical delay at the left ventricular (LV) pacing site on acute hemodynamic response with cardiac resynchronization therapy (CRT) has been investigated only in small observational studies.
Objectives: This study evaluates the impact of electrical delay, as assessed by interventricular (right ventricular-LV]) interval, on the acute hemodynamic response to CRT in a large, diverse multicenter cohort.
Methods: A total of 144 patients in 3 prospective studies, the PATH-CHF (Pacing Therapies in Congestive Heart Failure) I and II and the CRTAVO (CRT Optimization Algorithm Validation Study), were pooled and analyzed.
A Rare Presentation of Rheumatic Heart Disease: Severe Pulmonary Tricuspid and Mitral Stenosis Successfully Treated by Triple Balloon Valvuloplasty.
J Assoc Physicians India
March 2025
Associate, Department of Medicine, LN Medical College and JK Hospital, Bhopal, Madhya Pradesh, India.
This case report describes a unique occurrence of rheumatic heart disease (RHD) with severe mitral, tricuspid, and pulmonary stenosis in a 17-year-old female. The patient presented with progressive exertional dyspnea and dependent edema. She had a history of acute rheumatic fever and joint pain 5 years ago.
View Article and Find Full Text PDFA deep Bi-CapsNet for analysing ECG signals to classify cardiac arrhythmia.
Comput Biol Med
March 2025
University of Belgrade, Faculty of Transport and Traffic Engineering, Vojvode Stepe 305, Belgrade, 11010, Serbia; Yuan Ze University, College of Engineering, Department of Industrial Engineering and Management, Taoyuan City 320315, Taiwan. Electronic address:
- In recent times, the electrocardiogram (ECG) has been considered as a significant and effective screening mode in clinical practice to assess cardiac arrhythmias. Precise feature extraction and classification are considered as essential concerns in the automated prediction of heart disease. A deep bi-directional capsule network (Bi-CapsNet) uses a new method based on an intelligent deep learning (DL) classifier model to make the classification process very accurate.
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