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Audiologic Outcomes After Cochlear Implantation in Prelingually Deaf Children Who Have Combined Anomalies or Disabilities.
Otol Neurotol
January 2025
Department of Otorhinolaryngology, Head & Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Objective: To evaluate the audiologic outcomes after cochlear implantation (CI) in prelingually deaf children with comorbid disorders.
Study Design: Retrospective study.
Setting: Tertiary care academic center.
Tiletamine/Zolazepam and Ketamine with Dexmedetomidine (TKD) Cocktail Is as Effective as Tiletamine/Zolazepam and Ketamine with Xylazine (TKX) in Providing Pig General Anesthesia.
Animals (Basel)
October 2024
Department of Veterinary Surgery, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
This study aimed to evaluate dexmedetomidine as an alternative to xylazine in pigs. We compared TKD (0.05 mL/kg) to TKX (0.
View Article and Find Full Text PDFWDR44 Loss-of-Function Promoter Deletion in a Male Newborn With a Ciliopathy Phenotype.
Am J Med Genet A
January 2025
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina, USA.
Gain-of-function variants in the WDR44 gene have recently been associated with an X-linked ciliopathy-related neurodevelopmental phenotype. Here, we report on a WDR44 loss-of-function (LOF) variant identified in the genome sequence from a male fetus enrolled in the Prenatal Genetic Diagnosis by Genomic Sequencing (PrenatalSEQ) multicenter study. The phenotype is consistent with the described X-linked ciliopathy that includes developmental delay, microcephaly, congenital heart defects, kidney abnormalities, cryptorchidism, musculoskeletal abnormalities, craniofacial dysmorphism, and effusions.
View Article and Find Full Text PDFChemical exposome and children health: Identification of dose-response relationships from meta-analyses and epidemiological studies.
Environ Res
December 2024
University Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France. Electronic address:
Article Synopsis
- A study reviewed the health impacts of various chemicals on children's health, focusing on 78 substance-outcome pairs previously deemed likely or very likely to affect health outcomes.* -
- The researchers found that 64% of these pairs had dose-response relationships, primarily derived from meta-analyses and single studies, covering substances like tobacco, lead, and pesticides.* -
- However, there were still 36% of the pairs for which no dose-response relationship could be identified, indicating gaps in the current understanding of chemical exposures' effects on children's health.*
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