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Computational analysis of the effect of a binding protein (RbpA) on the dynamics of Mycobacterium tuberculosis RNA polymerase assembly.
PLoS One
January 2025
Molecular Biophysics Unit, Indian Institute of Science, Bengaluru, Karnataka, India.
Article Synopsis
- RbpA is a critical protein for Mycobacterium tuberculosis growth, impacting transcription and antibiotic response, but its regulatory mechanisms are not fully understood.
- Significant structural changes in RNA polymerase occur when it interacts with RbpA, revealing important amino acids for transcription regulation and dynamic behavior of the complex.
- The study identifies potential ligands for RbpA's interaction site, laying the groundwork for future research on developing inhibitors that target RbpA's regulatory role in transcription.
Assessment of the underreporting of rhinitis in patients with asthma: A MASK-air® real-world study.
Pulmonology
December 2025
Department of Allergology, Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Rhinitis is a common comorbidity in patients with asthma. However, the frequency of underreported rhinitis in asthma is not known. In this study, we aimed to assess the characteristics of patients with self-reported asthma and no self-reported rhinitis, as well as the extent of the underreporting of rhinitis.
View Article and Find Full Text PDFAn analysis of knowledge, attitudes, practice and influencing factors for tuberculosis prevention and control among Hainan University students.
Front Public Health
January 2025
Department of Scientific Research, Hainan General Hospital, Haikou, China.
Objective: To assess the current status of knowledge, attitude, and practice pertaining to tuberculosis prevention among college students in Hainan Province, China, and to identify influential factors. The findings of this study are intended to provide valuable insights for the development and implementation of effective health education programs aimed at tuberculosis prevention and control.
Methods: A convenient sampling method was employed to conduct a questionnaire-based survey among college students at a university in Hainan Province using the Wenjuanxing platform from January to February 2023.
Cutaneous Presentation Mimicking Tuberculosis as an Initial Indicator of Hairy Cell Leukemia: A Case Report.
Cureus
December 2024
Internal Medicine, Hospital de Braga, Braga, PRT.
Hairy cell leukemia (HCL) is a rare and slow-progressing lymphoid disorder commonly presenting with splenomegaly and cytopenias. The diagnosis can be challenging due to its nonspecific clinical presentation, frequently resembling other diseases. We report the case of a 48-year-old male patient, whose initial diagnostic hypotheses included cutaneous tuberculosis and reactive arthritis, but the diagnosis was confirmed as HCL after further investigation, including flow cytometry.
View Article and Find Full Text PDFOvercoming Recurrent Isolated Sleep Paralysis: A Case Report of Integrative Management With Yoga, Meditation, and Vitamin D3 Supplementation.
Cureus
December 2024
Community Medicine, Terna Medical College, Navi Mumbai, IND.
Recurrent isolated sleep paralysis (RISP) is a rare but distressing condition characterized by episodes of temporary immobility during transitions between wakefulness and sleep. This report describes a 30-year-old female presenting frequently with nightmares, sleep paralysis, and associated stress, successfully managed with a holistic approach incorporating yoga, meditation, chanting, and vitamin D3 supplementation. The patient's significant history of osteoporosis (in February 2019, bone density T-score <-2.
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