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Effect of Hydrogen Sulfide on Sympathoinhibition in Obese Pithed Rats and Participation of K Channel.
Int J Hypertens
November 2024
Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de Los Tenorios 235, Col. Granjas-Coapa, Alc. Tlalpan, C.P. 14330, Ciudad de México, Mexico.
Elevated blood pressure is the leading metabolic risk factor in attributable deaths, and hydrogen sulfide (HS) regulates vascular tone and blood pressure. Thus, this study aims to evaluate the mechanism by which NaHS (HS donor) produces inhibition of the vasopressor sympathetic outflow in obese rats. For that purpose, animals were fed a high-fat diet (HFD) (60% calories from fat) for 12 weeks.
View Article and Find Full Text PDFNO-cGMP-K Channels Pathways Participate in the Antihypertensive Effects of Martius ex Spreng Oil-Loaded Nanocapsules.
Pharmaceutics
June 2024
Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados 79804-970, MS, Brazil.
Martius ex Spreng is a palm tree that is widely distributed in the Central-West region of Brazil. In this study, we investigated whether the oil-loaded nanocapsules of (APON) have acute and long-lasting antihypertensive effects in male spontaneously hypertensive rats (SHR), as well as explored the underlying molecular mechanisms. APON was prepared using the interfacial polymer deposition method.
View Article and Find Full Text PDFUnlabelled: Noise can induce hearing loss. In particularly, noise can induce cochlear synapse degeneration leading to hidden hearing loss, which is the most common type of hearing disorders in the clinic. Currently, there is no pharmacological treatment, particularly, no post-exposure (i.
View Article and Find Full Text PDFVasodilation and Blood Pressure-Lowering Effect of 3-Demethyl-2-Geranyl-4-Prenylbellidifoline, a Xanthone Obtained from , in Hypertensive Rats.
Plants (Basel)
February 2024
Postgraduate Program in Pharmaceutical Sciences, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI), Rua Uruguai, 458, Centro, Itajaí 88302-901, SC, Brazil.
3-demethyl-2-geranyl-4-prenylbellidifoline (DGP), a natural xanthone isolated from , has previously demonstrated remarkable diuretic and renal protective actions. The present study expands its actions on the cardiovascular system by evaluating its vasorelaxant and blood pressure-lowering effects in spontaneously hypertensive rats (SHRs). Aortic endothelium-intact (E+) preparations of SHRs pre-contracted by phenylephrine and exposed to cumulative concentrations of extract, fractions, and DGP exhibited a significant relaxation compared to vehicle-only exposed rings.
View Article and Find Full Text PDFAlkaloid uptake pathways in renal tubular epithelial cells from different processed products of Phellodendri chinensis Cortex.
J Pharm Biomed Anal
May 2024
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China. Electronic address:
This study aimed to investigate the absorption of alkaloids from Phellodendri chinensis Cortex (PC) by human renal tubular epithelial cells (HK-2). Cellular uptake and affinity ultrafiltration assays were employed to determine the alkaloid uptake pathway in HK-2 cells. Stemming from the hypothesis that salt-water processed PC introduces these alkaloids into the kidney at a cellular level, this research focused on different processed products of PC that are tailored for renal targeting.
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