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GABA receptor-mediated potentiation of ventral medial habenula glutamatergic transmission in GABAergic and glutamatergic interpeduncular nucleus neurons.
bioRxiv
January 2025
Department of Neurosciences and Psychiatry, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.
The medial habenula (MHb)-interpeduncular nucleus (IPN) pathway plays an important role in information transferring between the forebrain and the midbrain. The MHb-IPN pathway has been implicated in the regulation of fear behavior and nicotine addiction. The synapses between the ventral MHb and the IPN show a unique property, i.
View Article and Find Full Text PDFAn Unexpected Outcome of an Ischemic Stroke on the Reward Pathways in the Human Brain.
HCA Healthc J Med
December 2024
Del Sol Medical Center, El Paso, Texas.
Background: Addiction affects millions of people, often resulting from a complex interplay between genetic and environmental factors, and is frequently linked to mental health disorders. Many experts agree there is no cure for addiction, but there are effective treatments available. Many patients continue to succumb to addiction despite treatment.
View Article and Find Full Text PDFThe Implementation of the Biopsychosocial Model: Individuals With Alcohol Use Disorder and Post-Traumatic Stress Disorder.
Brain Behav
January 2025
Rehabilitation Psychology, Health Science Center, Texas Tech University, Lubbock, Texas, USA.
Introduction: This extensive literature review investigates the relationship between post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD), focusing on the neurobiological changes associated with their co-occurrence. Given that these disorders frequently coexist, we analyze mechanisms through which alcohol serves as a coping strategy for PTSD symptoms, particularly highlighting the drinking-to-cope self-medication model, which suggests that alcohol use exacerbates PTSD symptoms and complicates recovery.
Methods: A systematic literature search was conducted across multiple databases, including PubMed and Google Scholar, to identify studies examining the intersection of the biopsychosocial model with PTSD, AUD, and associated neural alterations.
A sex-specific effect of M muscarinic cholinergic autoreceptor deletion on locomotor stimulation by cocaine and scopolamine.
Front Mol Neurosci
December 2024
Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen, Mental Health Services in the Capital Region of Denmark and University of Copenhagen, Copenhagen, Denmark.
Objective: Acetylcholine modulates the activity of the direct and indirect pathways within the striatum through interaction with muscarinic M and M receptors. M receptors are uniquely positioned to regulate plasticity within the direct pathway and play a substantial role in reward and addiction-related behaviors. However, the role of M receptors on cholinergic neurons has been less explored.
View Article and Find Full Text PDFEvaluation of the Frequency of Migraine and CVA Patients Based on Circle of Willis Morphological Variations in MRA Images.
Adv Biomed Res
November 2024
Medical Faculty, Abadan University of Medical Sciences, Abadan, Iran.
Background: The Circle of Willis (CoW) forms a critical collateral route for the compensation pathway at the basal cistern of the brain. This study aims to determine if migraine headaches and cerebrovascular accidents (CVAs) are associated with the prevalence and patterns of CoW arterial variations seen in the three-dimensional time-of-flight magnetic resonance angiography technique in patients.
Materials And Methods: A cross-sectional study was undertaken by a systemic search of electronic databases in the Imaging Center, Abadan's Taleghani Hospital, Iran, from March 2020 to March 2022.
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