Atherosclerosis and its complications are prevalent worldwide with a high prevalence in western societies. The disease may sometimes be explained by a defect of low density lipoprotein (LDL) specific receptors. However, the prevalence of receptor defect is rather rare and a large body of evidence supports the possibility that an alternative pathway, the so-called "scavenger pathway", constitutes the gate through which cholesterol enters into the parietal wall and gives origin to the "foam cell". Experimental work has clearly demonstrated that LDL may be modified under the action of chemical and biological offenders, all of which make the LDL an "alien". Some papers suggest that the modifications of LDL may occur also "in vivo" in the microenvironment of the vascular vall. In 1988 we were able to record two LDL subfractions in human plasma; the more electronegative minor subfraction shares many of the peculiar traits of LDLs modified "in vitro". The present article stresses all the points which support the hypothesis that the small more electronegative LDL circulating modified LDL, may represent a certain amount of possibly oxidative in origin.
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http://dx.doi.org/10.1016/0021-9150(91)90198-c | DOI Listing |
Macromol Rapid Commun
January 2025
State Key Laboratory of Applied Organic Chemistry, Lanzhou Magnetic Resonance Center, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Residual dipolar coupling (RDC) not only contributes to the dynamic analysis of proteins but also provides a robust route for the structure determination of small organic compounds. An essential prerequisite for this methodology is the availability of alignment media. Herein, a series of novel peptide-based alignment media are generated by introducing D-type or halogen-bearing amino acids for RDC measurements.
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January 2025
Department of Physics, Lehigh University, Bethlehem, Pennsylvania 18015, United States.
DNA nucleobases are important in DNA sequencing, disease testing linked to genes, and disease treatment. Here, we report density functional calculations investigating the adsorption of guanine (G), adenine (A), thymine (T), and cytosine (C) on armchair graphene nanoribbons (AGNR) - a gapped semiconductor. Their adsorption energies, charge transfer, work function, and electrical properties were calculated.
View Article and Find Full Text PDFAmino Acids
January 2025
Faculty of Natural Sciences, University of SS Cyril and Methodius, 91701, Trnava, Slovakia.
Four aliphatic amino acids-α-aminobutyric acid (AABA), β-aminobutyric acid (BABA), α-aminoisobutyric acid (AAIBA) and β-aminoisobutyric acid (BAIBA) were investigated in water as a solvent by two quantum chemical methods. B3LYP hybrid version of DFT was used for geometry optimization and a full vibrational analysis of neutral molecules, their cations and anions in the canonical and zwitterionic forms (6 forms for each species). Ab initio DLPNO-CCSD(T) method was applied in the geometry pre-optimized by B3LYP.
View Article and Find Full Text PDFSmall
January 2025
School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, 200093, P. R. China.
Chlorophenols are difficult to degrade and mineralize by traditional advanced oxidation processes due to the strong electronegativity of chlorine. Here, a dual-site atomically dispersed catalyst (FeMoNC) is reported, which Fe/Mo supported on mesoporous nitrogen-doped carbon is prepared through high-temperature migration. The FeMoNC exhibits a high dechlorination rate of 93.
View Article and Find Full Text PDFSmall Methods
January 2025
Research Institute of Frontier Science, Southwest Jiaotong University, Chengdu, 610031, P. R. China.
Commercial 3D zinc foam anodes with high deposition space and ion permeation have shown great potential in aqueous ion batteries. However, the local accumulated stress from its high-curvature surface exacerbates the Zn dendrite issue, leading to poor reversibility. Herein, we have employed zincophilic N-doped carbon@Sn composites (N-C@Sn) as nano-fillings to effectively release the local stress of high curvature surface of 3D Zn foams toward dendrite-free anode in aqueous zinc ion battery (AZIB).
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