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Population-Based Incidence of Infectious Mononucleosis and Related Hospitalizations: 2010 Through 2021.
Mayo Clin Proc
March 2025
Moderna, Inc, Cambridge, MA.
Objective: To determine whether the risks of infectious mononucleosis (IM) and serious IM outcomes are changing over time.
Patients And Methods: Individuals with a diagnosis of IM and hospitalizations due to IM were identified among persons residing in an Upper Midwest region between January 1, 2010, and December 31, 2021, using the Rochester Epidemiology Project. Infectious mononucleosis rates were calculated assuming the entire population between 2010 and 2021 was at risk, and IM-associated hospitalization rates were calculated among everyone with a diagnosis of IM.
Guillain-Barré Syndrome Initially Perceived as Unilateral Facial Palsy in Epstein-Barr Virus Infection.
Cureus
February 2025
Otolaryngology - Head and Neck Surgery, Ageo Central General Hospital, Ageo, JPN.
We encountered a case of a 21-year-old female presenting with unilateral peripheral facial nerve palsy, initially suspected to be triggered by Epstein-Barr virus (EBV) infection. The patient initially complained of numbness in both lower extremities, progressing to difficulty with mobility by day two, leading to emergency admission. Despite an initial evaluation by a neurologist in the emergency department, Guillain-Barré Syndrome (GBS) was not diagnosed, and she was admitted to internal medicine for further investigation.
View Article and Find Full Text PDFImpact of lifestyle factors post-infectious mononucleosis on multiple sclerosis risk.
Eur J Epidemiol
March 2025
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Background: Accumulating evidence suggest that Epstein-Barr virus (EBV) is crucial in the development of multiple sclerosis (MS), with inadequate infection control possibly contributing to disease onset. Past infectious mononucleosis (IM) has been found to interact with smoking, obesity, and sun exposure. We aimed to investigate potential interactions between a history of IM and the following risk factors for MS: passive smoking, alcohol consumption, fish consumption, vitamin D status, adolescent sleep duration and sleep quality.
View Article and Find Full Text PDFHigh Epstein-Barr Virus DNA Load in T Cells Predicts Hemophagocytic Lymphohistiocytosis.
J Infect Dis
February 2025
Department of Infectious Diseases, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Background: To evaluate the risk of hemophagocytic lymphohistiocytosis (HLH) linked to Epstein-Barr virus (EBV) infection in different lymphocyte subtypes during infectious mononucleosis (IM).
Methods: Patients with IM and patients with EBV-HLH were included within the Children's Critical EBV Infection cohort for a nested case-control study. Lymphocytes were isolated into T, B, and natural killer cells using magnetic bead sorting, followed by individual polymerase chain reaction testing.
Nonlinear physics perspective and essential disease dynamics of EBV infections and the dynamics of EBV-associated diseases.
J Biol Phys
February 2025
Psychological Sciences, University of Connecticut, 406 Babbidge Road, 06269, Storrs, CT, USA.
The Epstein-Barr virus affects more than 90% of the world population and, consequently, is a virus whose infection dynamics should not be overlooked. It can cause the disease infectious mononucleosis and comes with other virus-associated diseases and conditions ranging from certain cancers to episodes of fatigue and depression. While previous epidemiological and virological modeling studies have worked out the details of possible infection dynamics scenarios, the current study takes a different approach.
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