AI Article Synopsis
- The study analyzed cholesteryl esters in the serum of obese children and adolescents using a high-performance liquid chromatography method, which effectively separated cholesterol and its esters.
- Researchers tested the impact of external factors like physical stress and diet on the levels of cholesteryl esters in obese teens aged 13 to 16.
- Findings showed that while external conditions didn’t significantly alter individual cholesteryl ester levels, a notable decrease in total cholesterol was observed after spa treatment.
Article Abstract
The serum of obese children and adolescents was analyzed for cholesteryl esters. The test substances were first separated from the sample matrix by solvent extraction and thin-layer chromatography and then resolved in a reversed-phase high-performance liquid chromatographic system involving a Separon SGX C18 column and a mobile phase of 2-propanol-acetonitrile (40:60, v/v), with ultraviolet detection at 206 nm. Cholesterol and 10-cholesteryl esters could be separated and determined within ca. 25 min at a flow-rate of 1 ml/min. The method was applied to a study of the effect of external conditions (physical stress, diet) on the content of cholesteryl esters in a test group of obese boys and girls aged from 13 to 16 years. The analyses have demonstrated that the above conditions do not affect the concentrations of the individual cholesteryl esters, although the total cholesterol concentration decreased significantly after spa treatment.
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| http://dx.doi.org/10.1016/0378-4347(91)80430-k | DOI Listing |
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