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Disentangling the role of executive function and episodic memory in older adults' performance on dynamic theory of mind tasks.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn
March 2025
Department of Psychological & Brain Sciences, Indiana University, Bloomington, USA.
Theory of mind is a core social cognitive ability, and declines over the lifespan. Prior work examining the mechanisms underlying older adults' theory of mind deficits has yielded heterogenous results. One reason for this might be a general reliance on static, rather than dynamic, stimuli.
View Article and Find Full Text PDF: A Comprehensive View of the Proteome.
J Proteome Res
March 2025
Microbiology and Parasitology Department, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.
We describe a new release of the PeptideAtlas proteomics spectral resource (build 2024-03), providing a sequence coverage of 79.5% at the canonical protein level, matched mass spectrometry spectra, and experimental evidence identifying 3382 and 536 phosphorylated serine and threonine sites with false localization rates of 1% and 5.3%, respectively.
View Article and Find Full Text PDFExternal quality assessment of molecular detection and variant typing of SARS-CoV-2 in European expert laboratories in 2023.
J Clin Microbiol
March 2025
Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humbolt-Universität zu Berlin, Berlin, Germany.
The COVID-19 pandemic highlighted the importance of laboratory preparedness. Regular monitoring of diagnostic tools via external quality assessments (EQAs) is key to maintaining robust public health response service. We hereby conducted a third SARS-CoV-2 EQA assessing the diagnostic capabilities of European expert public health laboratories.
View Article and Find Full Text PDFCalibration of additional computational tools expands ClinGen recommendation options for variant classification with PP3/BP4 criteria.
Genet Med
March 2025
Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:
Purpose: We previously developed an approach to calibrate computational tools for clinical variant classification, updating recommendations for the reliable use of variant impact predictors to provide evidence strength up to Strong. A new generation of tools using distinctive approaches has since been released, and these methods must be independently calibrated for clinical application.
Method: Using our local posterior probability-based calibration and our established data set of ClinVar pathogenic and benign variants, we determined the strength of evidence provided by three new tools (AlphaMissense, ESM1b, VARITY) and calibrated scores meeting each evidence strength.
Inferring networks of chemical reactions by curvature analysis of kinetic trajectories.
Phys Chem Chem Phys
March 2025
Department of Electrical and Systems Engineering, Washington University, 1 Brookings Dr, St. Louis, MO, 63130, USA.
Quantifying interaction networks of chemical reactions allows description, prediction, and control of a range of phenomena in chemistry and biology. The challenge lies in unambiguously assigning contributions to changes in rates from different interactions. We propose that the curvature change of kinetic trajectories due to a systematic perturbation of a node in a network can identify the coupling strength and topology.
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