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tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination.
Research (Wash D C)
January 2025
Department of Neurosurgery and Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266000, People's Republic of China.
Transfer RNA-derived small RNAs, a recently identified class of small noncoding RNAs, play a crucial role in regulating gene expression and are implicated in cerebrovascular diseases. However, the specific biological roles and mechanisms of transfer RNA-derived small RNAs in intracranial aneurysms (IAs) remain unclear. In this study, we identified that the transfer RNA-Asp-GTC derived fragment (tRF-AspGTC) is highly expressed in the IA tissues of both humans and mice.
View Article and Find Full Text PDFGiant left atrial appendage aneurysm: a source of multiple thrombotic events despite medical therapy.
Eur Heart J
January 2025
School of Medicine, Vita-Salute San Raffaele University, Via Olgettina 58, Milan 20132, Italy.
Transapical coil embolization for subannular aortic pseudoaneurysm.
Multimed Man Cardiothorac Surg
January 2025
Aortic pseudoaneurysm is a rare but life-threatening complication following aortic surgery. Although surgical repair remains the gold standard for treatment, alternative approaches such as transcatheter strategies are increasingly considered viable options, particularly in patients with high surgical risk due to comorbidities, anatomical challenges or technical constraints. We present the case of a 72-year-old male patient who developed a subaortic pseudoaneurysm during radiological follow-up after a previous Bentall operation.
View Article and Find Full Text PDFThe Nonsyndromic Ascending Thoracic Aorta in a Population-Based Setting: A 5-Year Prospective Cohort Study.
J Am Coll Cardiol
November 2024
Elite Centre for Individualized Medicine in Arterial Disease, Odense University Hospital, Odense, Denmark; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Background: Prospective data on the clinical course of the ascending thoracic aorta are lacking.
Objectives: This study sought to estimate growth rates of the ascending aorta and to evaluate occurrences of adverse aortic events (AAEs)-that is, thoracic aortic ruptures, type A aortic dissections, and thoracic aortic-related deaths.
Methods: In this prospective cohort study from the population-based, multicenter, randomized DANCAVAS (Danish Cardiovascular Screening trials) I and II, participants underwent cardiovascular risk assessments including electrocardiogram-gated, noncontrast computed tomography (CT) scans.
Does Ascending Aortic Size Matter?: A Plea for Patient-Specific Surveillance and Risk Estimation.
J Am Coll Cardiol
December 2024
Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Sydney Adventist Hospital, Sydney, New South Wales, Australia; Maquarie University Hospital, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
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