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The effect of ranger patrols on the sighting of large mammals by local herders in Northern Iran.
Heliyon
January 2025
Department of Environment, Mazandaran Provincial Office, Mazandaran, Iran.
Ranger patrols are essential for biodiversity conservation, particularly in protected areas where they help mitigate poaching of large mammals. Effective patrols reduce poaching and support higher population densities of large mammals. This study investigates the impact of ranger patrols on large mammal sightings in the Central Alborz Protected Area (CAPA), northern Iran, a crucial wildlife corridor with UNESCO-listed Hyrcanian forests and high-altitude grasslands.
View Article and Find Full Text PDFA novel sensitizer reduces EGFR-TKI resistance by regulating the PI3K/Akt/mTOR pathway and autophagy.
Heliyon
January 2025
First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, PR China.
Background: The incidence and mortality of lung cancer are high, and treatment with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is the preferred first-line treatment for patients suffering from non-small cell lung cancer (NSCLC) with EGFR mutations. However, EGFR-TKI resistance leads to treatment failure. Yifei-Sanjie pill (YFSJ) is a novel type of Chinese patent medicine for lung cancer.
View Article and Find Full Text PDFTyre rubber exposure causes oxidative stress and intracellular damage in the Baltic clam (Macoma balthica).
Environ Sci Pollut Res Int
January 2025
Marine and Freshwater Solutions, Finnish Environment Institute, Latokartanonkaari 11, 00790, Helsinki, Finland.
Car tyres are considered to release a substantial amount of particles to the environment. Due to the high emission volumes and the chemical risks associated with tyre rubber, there is an urgent need to quantify their ecotoxicological effects. The effects of exposure to particles derived from end-of-life tyres were investigated on the Baltic clam (Macoma balthica), which is one of the key invertebrate species living in the soft-bottom sediments of the northern Baltic Sea.
View Article and Find Full Text PDFMorpho-functional characterisation of cœlomocytes in the aquacultivated sea cucumber Holothuria scabra: from cell diversity to transcriptomic immune response.
Fish Shellfish Immunol
January 2025
Biology of Marine Organisms and Biomimetics Unit, Research Institute for Biosciences, University of Mons (UMONS), 7000 Mons, Belgium; Laboratory of Cellular and Molecular Immunology, GIGA Research, University of Liège, 4000 Liège, Belgium.
Holothuria scabra is one of the most valuable species of sea cucumber owing to its exploitation as a seafood product. This study aims to describe the main molecular and cellular actors in the immunology of the holothuroid H. scabra.
View Article and Find Full Text PDFA novel neutralizing antibody recognizing a conserved conformational epitope in PDCoV S1 protein and its therapeutic efficacy in piglets.
J Virol
January 2025
Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Unlabelled: Porcine deltacoronavirus (PDCoV) is an enteric pathogen that burdens the global pig industry and is a public health concern. The development of effective antiviral therapies is necessary for the prevention and control of PDCoV, yet to date, there are few studies on the therapeutic potential of PDCoV-neutralizing antibodies. Here, we investigate the therapeutic potential of a novel monoclonal antibody (mAb 4A6) which targets the PDCoV S1 protein and effectively neutralizes PDCoV, both pre- and post-attachment on cells, with IC50 values of 0.
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