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Identification of hypothermia-inducing neurons in the preoptic area and activation of them by isoflurane anesthesia and central injection of adenosine.

J Physiol Sci

January 2025

Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8-35-1, 890-8544, Kagoshima, Japan. Electronic address:

Hibernation and torpor are not passive responses caused by external temperature drops and fasting but are active brain functions that lower body temperature. A population of neurons in the preoptic area was recently identified as such active torpor-regulating neurons. We hypothesized that the other hypothermia-inducing maneuvers would also activate these neurons.

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Background: Medicinal plants are widely used for healthcare needs, including oral health. In the Philippines, garlic, guava, tsaang-gubat, and hierba buena, although primarily recognized as plants used for the treatment of systemic diseases, are indicated as analgesics for dental pain, treatment of gingival inflammation, and oral health maintenance. Despite studies focusing on the effectiveness of these plants for oral health, there is little to no research on the populace's knowledge, attitude, and practices on these medicinal plants.

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Analgesic Overdose in Patients With Dental Pain. A Cross-Sectional Study in Two Dental Emergency Clinics.

Basic Clin Pharmacol Toxicol

February 2025

Department of Odontology, Section of Oral Biology and Immunopathology, University of Copenhagen, Copenhagen, Denmark.

Dental pain is common, and many patients use analgesics to alleviate the pain. Analgesics are readily accessible, and overdosing may lead to severe complications. This study explores the extent of analgesic overdosing in patients with dental pain.

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With over two millennia of history, traditional Chinese acupuncture ranks among the most renowned forms of supplementary and other healthcare. The use of acupuncture releases endorphins and serotonin, two naturally occurring painkillers, into the nervous system and stimulates it. It also modifies how pain signals are processed and perceived.

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Treatment outcomes in adult patients experiencing dental anxiety: A comparative retrospective study.

Spec Care Dentist

January 2025

Department of Periodontology, Faculty of Dental Medicine, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.

Aims: To assess and compare the effectiveness of pharmacological and cognitive-behavioral modalities-behavioral methods (BM), nitrous oxide inhalation sedation (NOIS), and premedication with Diazepam-for alleviating anxiety during dental treatment, using completed treatment sessions and adverse outcomes as indicators.

Methods And Results: For 239 patients (515 dental records), 18-53 y/o, who underwent dental treatments under anxiety reduction measures, sessions under NOIS were categorized as "nitrous group" (456 sessions) versus premedication with Diazepam or behavioral strategies (control, 59 sessions). Outcomes were completed treatment sessions considering demographic and clinical parameters, and adverse outcomes during and between sessions.

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