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Could Pulsed Wave Tissue Doppler Imaging Solve the Diagnostic Dilemma of Right Atrial Masses and Pseudomasses? A Case Series and Literature Review.
J Clin Med
December 2024
Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.
Even if rarely detected, right atrial (RA) masses represent a diagnostic challenge due to their heterogeneous presentation. Para-physiological RA structures, such as a prominent Eustachian valve, Chiari's network, and lipomatous atrial hypertrophy, may easily be misinterpreted as pathological RA masses, including thrombi, myxomas, and vegetations. Each pathological mass should always be correlated with adequate clinical, anamnestic, and laboratory data.
View Article and Find Full Text PDFIntroduction: Chimeric antigen receptor T-cell (CAR-T) therapy is highly effective in B-cell blood cancers, but there is limited data on its safety and efficacy in intra-cardiac lymphoma, due to the potential risks of cardiotoxicity and pseudo-progression.
Discussion: We discuss four high-risk cases that were managed with a multi-disciplinary approach, including baseline cardiac risk assessment and surveillance with multimodal cardiac imaging and serum cardiac biomarkers, elective supportive care in the intensive care unit, and early treatment of cytokine release syndrome.
Conclusion: CAR-T therapy can be effective and safe in the treatment of B-cell blood cancers with intra-cardiac disease.
Aggressive Synchronous Papillary and Likely Follicular Thyroid Carcinomas in a Patient with Graves' Disease.
J ASEAN Fed Endocr Soc
December 2024
Department of Endocrinology, Singapore General Hospital.
Article Synopsis
- - The case centers on a 67-year-old woman with both papillary and follicular thyroid carcinomas, initially diagnosed with thyrotoxicosis from Graves' disease, presenting with severe metastasis and invasive tumor growth.
- - Investigation revealed multiple metastases, including intra-cardiac tumor thrombus and bone fractures, leading to a diagnosis of synchronous thyroid cancer types, yet the patient chose palliative care over aggressive treatment options.
- - The case highlights the challenges in accurately diagnosing synchronous thyroid malignancies and the limitations of the ACR TI-RADS system in detecting certain ultrasonographic features that indicate cancer, especially in patients with Graves' disease.
Assessment of the clinical and laboratory risk factors for thrombosis in neonates admitted to neonatal intensive care unit (two Egyptian tertiary centers experience).
Ann Hematol
November 2024
Pediatric Department, Minia University, Al Minya, Egypt.
In neonates admitted to the neonatal intensive care unit (NICU), arterial and venous thromboembolism is a major cause of morbidity and death which could be attributed to multiple risk factors exposure. This study aimed to evaluate the clinical characteristics, laboratory and radiological assessments, predisposing risk factors, and outcomes of thrombosis in neonates admitted to NICU. This prospective cohort study was conducted at NICU, Minia, and Alexandria University Children's Hospital.
View Article and Find Full Text PDFIn-Hospital Outcomes of Ventricular Tachycardia Catheter Ablation in the Presence of Intra-Cardiac Thrombus.
Pacing Clin Electrophysiol
November 2024
Division of Cardiovascular Medicine, Hillel Yaffe Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Article Synopsis
- A study evaluated the impact of intracardiac thrombi on in-hospital outcomes following ventricular tachycardia (VT) catheter ablation using a large US inpatient database from 2016 to 2019.
- Among 15,725 patients analyzed, only 190 (1.2%) had an intracardiac thrombus, showing these patients had more health issues, including ischemic cardiomyopathy and cardiac aneurysm.
- While complications were more frequent in patients with thrombus (42.1% vs. 19.3%), in-hospital mortality rates were similar for both groups, indicating that having a thrombus shouldn't prevent VT ablation if necessary, though care should be taken to manage complications.
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