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Misses and Near Misses in Paediatric Appendicitis: An Eight-Year, Single-Centre Retrospective Review.
Acta Paediatr
January 2025
Department of Pathology, Sourasky Medical Center, Tel Aviv, Israel.
Aim: Diagnostic error can result in the appendectomy of a normal appendix, commonly known as negative appendectomy (NA). Missed appendicitis (MA) is related to a poor outcome. The aim of this study was to determine whether there are factors in presentation associated with NA or MA.
View Article and Find Full Text PDFMachine-learning-assisted Preoperative Prediction of Pediatric Appendicitis Severity.
J Pediatr Surg
January 2025
McGill University Faculty of Medicine and Health Sciences, Canada; Harvey E. Beardmore Division of Pediatric Surgery, The Montreal Children's Hospital, McGill University Health Centre, Montreal, Qc, Canada.
Purpose: This study evaluates the effectiveness of machine learning (ML) algorithms for improving the preoperative diagnosis of acute appendicitis in children, focusing on the accurate prediction of the severity of disease.
Methods: An anonymized clinical and operative dataset was retrieved from the medical records of children undergoing emergency appendectomy between 2014 and 2021. We developed an ML pipeline that pre-processed the dataset and developed algorithms to predict 5 appendicitis grades (1 - non-perforated, 2 - localized perforation, 3 - abscess, 4 - generalized peritonitis, and 5 - generalized peritonitis with abscess).
Retrospective analysis of criteria for oncological completion surgery of neuroendocrine tumors of the appendix.
Langenbecks Arch Surg
January 2025
Department of Visceral, Thoracic and Vascular Surgery, Philipps-Universität Marburg, Baldingerstraße, Marburg, 35043, Germany.
Purpose: Neuroendocrine neoplasms of the appendix (aNET) are rare tumors that are often diagnosed by pathology as an incidental finding after appendectomy for acute appendicitis. Several guidelines proposed risk criteria to indicate oncological completion surgery after appendectomy. The aim of this study was to evaluate the reliability of proposed criteria for completion surgery of aNET.
View Article and Find Full Text PDFAntibiotic treatment versus appendicectomy for acute appendicitis in adults: an individual patient data meta-analysis.
Lancet Gastroenterol Hepatol
January 2025
Department of Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands. Electronic address:
Background: Randomised controlled trials (RCTs) have found antibiotics to be a feasible and safe alternative to appendicectomy in adults with imaging-confirmed acute appendicitis. However, patient inclusion criteria and outcome definitions vary greatly between RCTs. We aimed to compare antibiotics with appendicectomy for the treatment of acute appendicitis using individual patient data and uniform outcome definitions.
View Article and Find Full Text PDFComparison of Postoperative Antibiotic Protocols for Pediatric Complicated Appendicitis: A Western Pediatric Surgery Research Consortium Study.
J Pediatr Surg
January 2025
Division of Pediatric Surgery, Rady Children's Hospital San Diego, San Diego, CA, USA; Division of Pediatric Surgery, Dept of General Surgery, UCSD School of Medicine, La Jolla, CA, USA. Electronic address:
Background: There is no consensus on the appropriate duration of postoperative antibiotics for complicated appendicitis in children. Commonly used antibiotic endpoints include normalization of white blood cell count (WBC) or completion of a minimum number of prespecified treatment days. We compared clinical outcomes resulting from varying postoperative antibiotic protocols for complicated appendicitis in children.
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