Chondroitin sulfate (CS) is an endogenous component of cartilage which could determine osteoarthritis after radiolabeling. Radiolabeling was performed by (99m)TcO(4)(-)/tin method. We found that pH is a limiting factor. At pH 6.2 in 0.05 M Na acetate buffer 32.8% colloid was formed, at pH 5.0 in 0.5M Na acetate, in our methodology only 4.7% colloid. The tracer was highly stable. We conclude that (99m)TcCS could be a promising imaging agent of osteoarthritis due to simple radiolabeling and high stability.
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