A new synthetic model of arginine-carboxylate-aromatic triads-common motifs at sites of protein-protein interactions-is reported. Binding studies in mixed methanol/water solvent systems suggest that the carboxylate-binding ability of pi-stacked guanidinium ions is improved relative to a non-stacked control.
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| http://dx.doi.org/10.1021/ol7027042 | DOI Listing |
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