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DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis.
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Department of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
The DNA cross-link repair 1B (DCLRE1B) gene is involved in repairing cross-links between DNA strands, including those associated with Hoyeraal-Hreidarsson syndrome and congenital dyskeratosis. However, its role in tumours is not well understood. DCLRE1B expression profiles were examined in tumour tissues and normal tissues using TCGA, GTEx, and TARGET datasets.
View Article and Find Full Text PDFRole of P2X7 receptor in the progression and clinicopathological characteristics of gastric cancer.
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December 2024
Department of Gastroenterology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang city, Jiangxi province, China.
P2X7 receptor (P2X7R) plays a role in regulating tumor progression, but it is unclear whether P2X7R affects the pathological characteristics of patients with gastric cancer and the activity of gastric cancer cells. Therefore, this study preliminarily investigated the relationship between P2X7R and clinicopathological features of patients with gastric cancer, and further explored the effect of P2X7R on the proliferation, migration and invasion of gastric cancer cells through functional experiments. The results showed that P2X7R was highly expressed in gastric cancer tissues and gastric cancer cells.
View Article and Find Full Text PDFRoot exudates in mangrove forests accelerate bicarbonate production in the soil environment.
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School of Environmental Science, The University of Shiga Prefecture, Hassakacho, Hikone, 2500, 522-8533, Japan.
Mangrove forests are increasingly recognized as vital blue carbon ecosystems due to their high carbon sequestration capacity, primarily through the accumulation of soil organic carbon (SOC). Recent research highlights that, in addition to SOC, dissolved inorganic carbon (DIC), particularly in the form of bicarbonate (HCO₃⁻), plays a crucial role in carbon sequestration by being exported from these ecosystems to adjacent coastal waters. This study aims to investigate the previously unexamined mechanisms behind bicarbonate production in mangrove soils.
View Article and Find Full Text PDFA Greedy Tabu Dual Heuristic algorithm for the cyclic pickup and delivery problem with 3D loading constraints.
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Shandong University of Science and Technology, College of Transportation, Qingdao, 266590, China.
The optimization of auto parts supply chain logistics plays a decisive role in the development of the automotive industry. To reduce logistics costs and improve transportation efficiency, this paper addresses the joint optimization problem of multi-vehicle pickup and delivery transportation paths under time window constraints, coupled with the three-dimensional loading of goods. The model considers mixed time windows, three-dimensional loading constraints, cyclic pickup and delivery paths, varying vehicle loads and volumes, flow balance, and time window constraints.
View Article and Find Full Text PDFThe chromatin remodeling factor OsINO80 promotes H3K27me3 and H3K9me2 deposition and maintains TE silencing in rice.
Nat Commun
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State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.
The INO80 chromatin remodeling complex plays a critical role in shaping the dynamic chromatin environment. The diverse functions of the evolutionarily conserved INO80 complex have been widely reported. However, the role of INO80 in modulating the histone variant H2A.
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