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The Association Between Antipsychotics and Bone Fragility: An Updated Comprehensive Review.
Diagnostics (Basel)
December 2024
Psychiatry Unit, Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
Background: Antipsychotic drugs appear to be related to reduced bone mineral density (BMD). We conducted a narrative review to collect the available literature investigating the relationship between antipsychotic use and bone fragility.
Methods: A review of the published literature was conducted and reported through PubMed/Scopus/Cochrane libraries.
Exploring Systemic Comorbidities and Lifestyle Factors Associated With Seborrheic Dermatitis: A Scoping Review.
Cureus
November 2024
Department of Internal Medicine, South County Hospital, Warwick, USA.
Seborrheic dermatitis (SD), a chronic inflammatory skin condition consisting of itchy, red patches with greasy scales, has been linked to numerous systemic conditions. This review evaluates comorbidities and lifestyle factors that are associated with seborrheic dermatitis. A literary search was conducted in August 2024 using EMBASE, PubMed, and Medline Industries, and evaluated according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
View Article and Find Full Text PDFGenetic variants associated with longevity in long-living Indians.
NPJ Aging
November 2024
Mapmygenome India Limited, Hyderabad, India.
Article Synopsis
- Genetic factors significantly influence how long individuals live, and this study focuses on identifying these genetic variants in the Indian population by comparing individuals aged 85+ (long living individuals, LLIs) with younger controls aged 18-49.
- The research utilized a custom chip for genetic data, revealing 9 variants linked to longevity, with certain alleles associated with positive traits like slower heart rate and lower risks for various disorders being more common in LLIs, while other risky alleles were less frequent.
- The study also found that genes related to oxidative stress, DNA repair, and metabolism play important roles in healthy aging and longevity, confirming the genetic basis for these traits in the population.
Background: Risperidone (RIS) is the first-line drug in the clinical treatment of schizophrenia, and long-term use may lead to bone loss and even osteoporosis. This study investigated whether the mechanism of RIS-induced bone loss is related to autophagy.
Methods: The schizophrenia mice were established with the administration of MK-801.
Prognostic Factors of Hip Fracture in Elderly: A Systematic Review.
Int J Prev Med
August 2024
MD, PhD in Epidemiology, Trauma Research Center, Department of Community Medicine, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Article Synopsis
- * Key risk factors identified include age, substance use, sensory impairments, low BMI, past falls, weakness, and chronic diseases like stroke, diabetes, and osteoporosis.
- * The research suggests that certain changeable risk factors should be addressed by health policymakers to enable early interventions and reduce the incidence of hip fractures among the elderly.
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