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Retinol-binding protein and retinol analysis in cerebrospinal fluid and serum of patients with and without idiopathic intracranial hypertension. | LitMetric

AI Article Synopsis

  • This study investigates the connection between vitamin A-related compounds and idiopathic intracranial hypertension (IIH) by comparing cervico-spinal fluid (CSF) and serum levels of retinol and retinol-binding protein (RBP) in affected subjects and controls.
  • Sample analysis involved 87 participants, including 28 with IIH, 42 with other neurological issues, and 17 who were neurologically healthy.
  • Results showed that subjects with IIH had a higher retinol/RBP ratio in CSF compared to serum, indicating a potential role of vitamin A in the development of IIH, warranting further research into vitamin A and RBP correlations.

Article Abstract

Background: Several studies have implicated vitamin A-related compounds in the pathogenesis of idiopathic intracranial hypertension (IIH). The goal of this study was to compare cerebrospinal fluid (CSF) and serum concentrations of retinol and retinol-binding protein (RBP) in subjects with and without IIH.

Methods: CSF and serum samples were collected from 87 subjects. The study population was composed of subjects with IIH (IIH group, n = 28), subjects with non-IIH neurologic conditions (neurology controls, n = 42), and subjects undergoing preoperative lumbar puncture but with no known neurologic conditions (anesthesia controls, n = 17). RBP levels (nM) were determined using radial immunodiffusion, and retinol levels (nM) were determined using high-performance liquid chromatography.

Results: The retinol/RBP ratio was greater in CSF than in serum, especially in subjects with IIH.

Conclusions: The finding of increased levels of unbound retinol in the CSF of subjects with IIH provides further evidence that vitamin A may be involved in the pathogenesis of IIH. Comparative statistical analyses revealed multivariate relationships that demonstrate the need to further investigate correlations between vitamin A and RBP levels in CSF and serum.

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http://dx.doi.org/10.1097/WNO.0b013e31815b9af0DOI Listing

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