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Organelle-Targeting Nanoparticles.
Adv Sci (Weinh)
January 2025
Interdisiplinary program in Genetics and Genomics, Texas A&M University, College Station, TX, 77843, USA.
Organelles are specialized subunits within cells which carry out vital functions crucial to cellular survival and form a tightly regulated network. Dysfunctions in any of these organelles are linked to numerous diseases impacting virtually every organ system in the human body. Targeted delivery of therapeutics to specific organelles within the cell holds great promise for overcoming challenging diseases and improving treatment outcomes through the minimization of therapeutic dosage and off-target effects.
View Article and Find Full Text PDFIntegrating 3D printing of biomaterials with nitric oxide release.
Biomater Sci
January 2025
Institute of Chemistry, University of Campinas, UNICAMP, Campinas 13083-970, São Paulo, Brazil.
The pivotal roles played by nitric oxide (NO) in tissue repair, inflammation, and immune response have spurred the development of a wide range of NO-releasing biomaterials. More recently, 3D printing techniques have significantly broadened the potential applications of polymeric biomaterials in biomedicine. In this context, the development of NO-releasing biomaterials that can be fabricated through 3D printing techniques has emerged as a promising strategy for harnessing the benefits of localized NO release from implantable devices, tissue regeneration scaffolds, or bandages for topical applications.
View Article and Find Full Text PDFThe effect of microenvironmental viscosity on the emergence of colon cancer cell resistance to doxorubicin.
J Mater Chem B
January 2025
Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, Ibaraki 305-0044, Japan.
The colon possesses a unique physiological environment among human organs, where there is a highly viscous body fluid layer called the mucus layer above colonic epithelial cells. Dysfunction of the mucus layer not only contributes to the occurrence of colorectal cancer (CRC) but also plays an important role in the development of chemoresistance in CRC. Although viscosity is an essential property of the mucus layer, it remains elusive how viscosity affects chemoresistance in colon cancer cells.
View Article and Find Full Text PDFElectrospinning based biomaterials for biomimetic fabrication, bioactive protein delivery and wound regenerative repair.
Regen Biomater
December 2024
Department of Trauma Surgery, Orthopaedic Surgery and Plastic Surgery, University Medical Center Göttingen, University of Göttingen, Göttingen 37075, Germany.
Electrospinning is a remarkably straightforward and adaptable technique that can be employed to process an array of synthetic and natural materials, resulting in the production of nanoscale fibers. It has emerged as a novel technique for biomedical applications and has gained increasing popularity in the research community in recent times. In the context of tissue repair and tissue engineering, there is a growing tendency toward the integration of biomimetic scaffolds and bioactive macromolecules, particularly proteins and growth factors.
View Article and Find Full Text PDFInduced Neural Stem Cell Transplantation in Spinal Cord Injury: Present Status and Next Steps.
Korean J Neurotrauma
December 2024
Department of Neurosurgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
Spinal cord injury (SCI) remains a significant clinical challenge, with no fully effective treatment available despite advancements in various therapeutic approaches. This review examines the emerging role of induced neural stem cells (iNSCs) as promising candidates for SCI treatment, highlighting their potential for direct neural regeneration and integration with host tissue. We explore the biology of iNSCs, their mechanisms of action, and their interactions with host tissue, including modulating inflammatory responses, promoting axonal growth, and reconstructing neural circuits.
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