A second liver resection due to recurrent colorectal liver metastases.

Arch Surg

Department of Digestive Surgery, University Hospital of Bordeaux, Ave de Magellan, Pessac 33604, Bordeaux, France.

Published: December 2007

AI Article Synopsis

  • A second liver resection for recurrent colorectal cancer metastases can be safely performed with low complication rates and offers similar survival benefits to a first hepatectomy.
  • Postoperative mortality was low at 2.5%, and morbidity rates were not significantly different between the first and second surgeries, indicating that repeat surgery is manageable.
  • Key factors affecting survival include the timing between surgeries and whether extrahepatic disease is present, with shorter intervals and extrahepatic disease being associated with diminished treatment benefits.

Article Abstract

Background: Repeat liver resection because of recurrent colorectal liver metastases can provide survival benefit with a low rate of complications.

Design: Retrospective study.

Participants: Forty patients who underwent a second hepatectomy because of liver metastases from colorectal cancer.

Main Outcome Measures: Short- and long-term results of a second hepatectomy and determination of prognostic factors.

Results: The postoperative mortality rate was 2.5%. The postoperative morbidity rate was not significantly different after a second hepatectomy compared with single hepatectomy (42.5% and 27.5%, respectively; P = .10). Transfusion requirement and hospital stay were comparable for both a single and a second hepatectomy. Three- and 5-year overall survival rates were 55% and 31%, respectively. Disease-free survival rates at 3 and 5 years were, respectively, 49% and 27%. The interval between first and second hepatectomies and the presence of extrahepatic disease were independently related to survival (multivariate analysis).

Conclusions: A second liver resection because of recurrent liver metastases from colorectal cancer is safe and provides a survival benefit similar to that with single hepatectomy. Our analysis suggests that the benefit of treatment is limited in patients who undergo a second hepatectomy within 1 year of the first operation and in those with extrahepatic disease.

Download full-text PDF

Source
http://dx.doi.org/10.1001/archsurg.142.12.1144DOI Listing

Publication Analysis

Top Keywords

second hepatectomy
20
liver metastases
16
liver resection
12
resection recurrent
12
second
8
second liver
8
recurrent colorectal
8
colorectal liver
8
survival benefit
8
metastases colorectal
8

Similar Publications

Application of ultrasound elastography and splenic size in predicting post-hepatectomy liver failure: Unveiling new clinical perspectives.

World J Gastroenterol

January 2025

Department of Gastroenterology, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.

In this article, we discuss the study by Cheng , published in the , focusing on predictive methods for post-hepatectomy liver failure (PHLF). PHLF is a common and serious complication, and accurate prediction is critical for clinical management. The study examines the potential of ultrasound elastography and splenic size in predicting PHLF.

View Article and Find Full Text PDF

Objective: To analyze the efficacy of indocyanine green fluorescence (ICG-F)-assisted laparoscopic hepatectomy in patients with hepatocellular carcinoma (HCC).

Methods: This retrospective study included 120 patients with HCC who underwent laparoscopic hepatectomy in The First Affiliated Hospital of Soochow University from February 2020 to November 2022. Among them, 58 patients underwent conventional laparoscopic surgery (laparoscopic group), and 62 patients underwent ICG-F assisted laparoscopic surgery (ICG-F group).

View Article and Find Full Text PDF

Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver malignancy that arises from second-order biliary epithelial cells. Its incidence is gradually increasing worldwide. Well-known risk factors have been described, although in many cases, they are not identifiable.

View Article and Find Full Text PDF

Objective: The objective of this study was to evaluate the efficacy and safety of TACE combined with 125I seeds (TACE-125I) in the treatment of recurrent HCC at complex sites after hepatectomy.

Methods: This study retrospectively analyzed the clinical data of recurrent HCC patients located at complex sites (such as large blood vessels, diaphragm dome, etc.) after hepatectomy from January 2012 to December 2023, all of whom received TACE-125I or TACE therapy.

View Article and Find Full Text PDF

GRINA alleviates hepatic ischemia‒reperfusion injury-induced apoptosis and ER-phagy by enhancing HRD1-mediated ATF6 ubiquitination.

J Hepatol

January 2025

Department of Minimal Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, China; Lead contact. Electronic address:

Background & Aims: Hepatic ischemia‒reperfusion injury (HIRI) is a critical complication of liver surgery and transplantation that contributes significantly to severe organ failure. GRINA, a calcium-regulating endoplasmic reticulum (ER) protein, plays an essential role in controlling the unfolded protein response; however, its role in HIRI remains unclear. The aim of this study was to investigate the function of GRINA in HIRI and explore its potential as a therapeutic target.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!