Based on the concepts of Leksell and on recommendations of different Swedish physicists on the use of linear accelerator for radiosurgical use, we developed a new methodology coupling the Talairach stereotactic system with a commercial linac. Anatomical facts encouraged us to use coronal angles of irradiation employing the angular displacement of the linac above the horizontal plane. Different coronal planes are obtained by rotation of the stereotactic frame. The center of the irradiated target coincides with the irradiation and rotation center of the linear accelerator. Multiple targets can be irradiated in the same session. We use as recommended a secondary collimator in heavy alloy. Special software was prepared after different dosimetric controls. The use of a PC allows us to employ 1-6 targets and different collimators to displace the isocenters in order to obtain geometrical isodose modification, and to change the value of each irradiation arc or portions of each arc in some minutes. Simple or sophisticated neurosurgical strategies can be applied in the treatment of frequently irregular shape and volume AVMs.
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http://dx.doi.org/10.1159/000099559 | DOI Listing |
Hypertension
January 2025
Accelerator for Clinical Transformation, Brigham and Women's Hospital, Boston, MA. (S.H., A.J.B., D.Z., S.K., K.W., D.G., C.P.C., B.M.S.).
Background: Hypertension is a major cardiovascular risk factor, yet traditional care often results in suboptimal blood pressure (BP) control at the population level. We implemented a remote hypertension management program that monitored home BP and titrated medications per algorithm. This study assessed the program's long-term effects by examining participants' office BP up to 42 months post-enrollment.
View Article and Find Full Text PDFMol Clin Oncol
March 2025
Department of Orthopaedics, Mianyang Central Hospital, Mianyang, Sichuan 621000, P.R. China.
Ultra-high dose rate radiotherapy defined as FLASH radiotherapy is a potential technology to improve local tumor therapeutic gain ratio. It relies on linear accelerator capable of delivering large doses in a single microsecond pulse (>40 Gy/sec). This therapy would lead to sparing of normal tissue which has been termed the FLASH effect.
View Article and Find Full Text PDFTalanta
January 2025
Shenzhen Key Laboratory of Organic Pollution Prevention and Control, School of Biomedical Engineering, Harbin Institute of Technology Shenzhen, Shenzhen, 518055, China. Electronic address:
In this study, a novel In₂S₃/MXene composite was developed as a co-reactant accelerator to enhance the chemiluminescence (CL) performance of the classical luminol-H₂O₂ system. The In₂S₃ and MXene heterojunction catalyzed the CL reaction through synergistic effect, facilitating the generation of reactive oxygen species and increasing CL intensities. This enhanced system was applied for the first time to detect an ultraviolet (UV) filter-benzophenone-3 (BP-3) by leveraging its light absorption property.
View Article and Find Full Text PDFEncouraging lab results bolster plans to harness a new kind of particle accelerator in x-ray sources.
View Article and Find Full Text PDFRadiat Oncol
January 2025
German Cancer Consortium (DKTK), partner site Tübingen, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Background: For radiotherapy of head and neck cancer (HNC) magnetic resonance imaging (MRI) plays a pivotal role due to its high soft tissue contrast. Moreover, it offers the potential to acquire functional information through diffusion weighted imaging (DWI) with the potential to personalize treatment. The aim of this study was to acquire repetitive DWI during the course of online adaptive radiotherapy on an 1.
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