AI Article Synopsis
- Malignant epithelial change in phyllodes tumors (PTs) is uncommon, with only six reported cases of ductal carcinoma in situ linked to PTs.
- A specific case is discussed where a PT featured an intraductal carcinoma that grew significantly over three months.
- The tumor displayed mild to moderate stromal cellularity and abnormal epithelial structures, including areas of severe hyperplasia and cribriform ductal carcinoma with comedo necrosis.
Article Abstract
Malignant epithelial change within a phyllodes tumor (PT) is a rare event. To our knowledge, only six cases of ductal carcinoma in situ arising in a PT have been reported in English. We report a case of PT with an intraductal carcinoma component, which grew rapidly to a huge size in 3 months. Histologically, the stromal element showed mild to moderate cellularity with few mitoses and mild nuclear atypia. The epithelial element consisted of irregularly dilated ducts with a phyllodes structure that had moderate to severe epithelial hyperplasia, and foci of cribriform ductal carcinoma in situ with comedo necrosis.
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| http://dx.doi.org/10.1007/s00595-007-3562-0 | DOI Listing |
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