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Validation of point-of-care tests used at in-home assessments among older adults in primary care.
Scand J Prim Health Care
November 2024
Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark.
Background: Diagnosing acute disease in older adults is challenged by vague and atypical symptoms. Point-of-care tests (POCTs) at home may improve diagnostics and clinical decision-making. We compared various POCT devices to routine testing in acutely ill older adults to assess their clinical reliability.
View Article and Find Full Text PDFEarly Versus Late Initiation of Direct Oral Anticoagulants After Ischemic Stroke in People With Atrial Fibrillation and Hemorrhagic Transformation: Prespecified Subanalysis of the Randomized Controlled ELAN Trial.
Circulation
July 2024
Department of Neurology (M.B.G., S.A., T.H., U.F.), Inselspital Bern University Hospital and University of Bern, Switzerland.
Background: Whether hemorrhagic transformation (HT) modifies the treatment effect of early compared with late initiation of direct oral anticoagulation in people with ischemic stroke and atrial fibrillation is unknown.
Methods: This is a post hoc analysis of the ELAN trial (Early Versus Late Initiation of Direct Oral Anticoagulants in Post-Ischaemic Stroke Patients With Atrial Fibrillation). The primary outcome was a composite of recurrent ischemic stroke, symptomatic intracranial hemorrhage, major extracranial bleeding, systemic embolism, or vascular death within 30 days.
Age and sex effects on paired-pulse suppression and prepulse inhibition of auditory evoked potentials.
Front Neurosci
April 2024
Department of Functioning and Disability, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan.
Article Synopsis
- - The study investigates how responses to auditory stimuli are influenced by prior stimuli using two measures: paired-pulse suppression (PPS) and prepulse inhibition (PPI), highlighting their roles in various diseases, particularly schizophrenia and Alzheimer's.
- - Normative data were collected from healthy participants (35 females and 32 males, aged 19-70) to analyze the effects of age and sex on PPS and PPI values, with specific auditory stimuli tested via electroencephalography.
- - Results indicated females exhibited stronger test responses but weaker inhibition across both measures; aging was associated with stronger responses and weaker inhibition in PPS, but not in PPI, suggesting that age and sex should be considered in future studies involving these auditory processing mechanisms
Root rot of spinach caused by and in Taiwan.
Plant Dis
April 2024
National Chung Hsing University, Department of Plant Pathology, 145 Xingda Rd., Taichung, Taiwan, 40227;
Article Synopsis
- A vegetable nursery in Taichung City, Taiwan, experienced significant spinach seedling production failures in September and October 2022-2023, with about 30% of seedlings showing stunting, yellowing, and root rot.
- Researchers identified a pathogen linked to the symptoms, with 81% of the plants showing association through genetic analysis of isolates.
- Phylogenetic analysis indicated that four isolates were identical to a known neotype strain and five isolates were very similar to a reference strain, confirming the presence of specific pathogenic organisms affecting spinach.
The genus Nephelobotys Munroe & Mutuura, 1970 is revised to include eight species. Three species, N. apiculata sp.
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