AI Article Synopsis
- - A number of 3,4,5-trisubstituted 1,2,4-4H triazole compounds were created to explore their effectiveness in inhibiting HIV-1 reverse transcriptase.
- - Researchers used X-ray crystallography to determine how these compounds bind to the HIV-1 reverse transcriptase enzyme.
- - The study identified crucial interactions between the synthesized triazole derivatives and the enzyme, which could help in the development of new HIV treatments.
Article Abstract
A series of 3,4,5-trisubstituted 1,2,4-4H triazole derivatives was synthesized and investigated for HIV-1 reverse transcriptase inhibition. An X-ray structure with HIV-1 RT secured the binding mode and allowed the key interactions with the enzyme to be identified.
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| http://dx.doi.org/10.1016/j.bmcl.2007.11.127 | DOI Listing |
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