AI Article Synopsis
- Electroconvulsive seizure thresholds were analyzed across three rat strains (Sprague-Dawley, Wistar, and Fischer) in both adolescent and adult stages.
- In adolescents, all strains showed similar seizure thresholds in the hindbrain and forebrain, but adult Fischer rats exhibited the lowest thresholds, while Sprague-Dawley rats had the highest.
- The study indicates that limbic seizure thresholds were highest in Fischer rats during adolescence, suggesting that further research is needed to understand the impact of strain and age on seizure responses.
Article Abstract
Electroconvulsive seizure thresholds were compared between adolescent and mature Sprague--Dawley, Wistar, and Fischer rats. All strains had similar hindbrain or forebrain seizure thresholds as adolescents. As adults, hindbrain or forebrain seizure thresholds were highest for Sprague--Dawley and lowest for Fischer rats. Conversely, limbic seizure thresholds during adolescence were highest for Fischer rats. Additional study is needed to better delineate strain and maturational effects on electroconvulsive seizure testing.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271073 | PMC |
| http://dx.doi.org/10.1016/j.eplepsyres.2007.11.001 | DOI Listing |
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