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One-Pot Fabrication of Kinetically Inert Ultrasmall Manganese(II) Chelate-Backboned Polymer Contrast Agents for High-Performance Magnetic Resonance Imaging.
Nano Lett
November 2024
Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Traditional macromolecules or nanoscale Mn chelate-based magnetic resonance imaging (MRI) contrast agents (CAs) suffer from complicated and laborious synthesis processes, relatively low kinetic stability and relaxivity, limiting their clinical applications. Herein, we fabricated a series of kinetically inert Mn chelate-backboned polymers, P(MnL-PEG), through a facile and one-pot polymerization process. Particularly, P(MnL-PEG)-3 demonstrates a significantly higher relaxivity of 23.
View Article and Find Full Text PDFRational Design of Mono-Substituted Gd-DOTA as Highly Stable and Efficient MRI Contrast Agents for Hepatobiliary and Inflammation Imaging.
J Med Chem
September 2024
Wenzhou Key Laboratory of Biophysics, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China.
Hepatobiliary-specific magnetic resonance imaging contrast agents (MRI CAs) play a crucial role in the early diagnosis of hepatocellular carcinoma (HCC). However, only two acyclic CAs, Gd-BOPTA and Gd-EOB-DTPA, exhibit unfavorable kinetic inertness. Our study focused on the development of superior stable innovative macrocyclic CAs.
View Article and Find Full Text PDFGadolinium Presence in Rat Skin: Assessment of Histopathologic Changes Associated with Small Fiber Neuropathy.
Radiology
January 2024
From the Department of MR and CT Contrast Media Research (J.B., J.L., G.J., T.F., H.P.) and Research and Pre-Clinical Statistics Group (H.F.U.), Bayer, Müllerstraße 178, 13353 Berlin, Germany; Department of In Vivo/Radioanalytics (A.T.) and Department of Bioanalytics LC-MS 3 & MALDI (U.T.), Bayer, Wuppertal, Germany; Department of Neuropharmacology, QPS Austria, Grambach, Austria (J.N., M.P.); and External Corporate Employment Resources, Bayer U.S., Whippany, NJ (T.B.).
Background The presence of gadolinium traces in the skin after administration of gadolinium-based contrast agents (GBCAs) raised safety concerns regarding a potential association with small fiber neuropathy (SFN). Purpose To investigate signs of SFN in rat foot pads by quantification of the intraepidermal nerve fiber density (IENFD) after multiple GBCA administrations and to evaluate gadolinium concentration, chemical species, and clearance. Materials and Methods Fifty rats received eight intravenous injections of either gadodiamide, gadobutrol, gadoterate, gadoteridol (8 × 0.
View Article and Find Full Text PDFNSF evaluation of gadolinium biodistribution in renally impaired rats: Using novel metabolic Gd2O3 nanoparticles coated with β-cyclodextrin (Gd2O3@PCD) in MR molecular imaging.
Magn Reson Imaging
April 2024
Department of Toxicology and Pharmacology, Toxicology and Poisoning Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Conventional gadolinium-based contrast agents used in MRI are linked to Nephrogenic Systemic Fibrosis (NSF) in patients with poor kidney function, prompting research into safer alternatives.
- A study introduced Gadolinium oxide nanoparticles (Gd2O3 NPs) coated with β-cyclodextrin to assess Gd biodistribution in rats with renal impairment, marking the first application of this method.
- Results indicated higher Gd concentrations in tissues from the new Gd2O3@PCD group without notable tissue damage, while showing that traditional agents like Omniscan led to worse histopathological outcomes compared to Dotarem.
Gadolinium-Based Contrast Agents and Free Gadolinium Inhibit Differentiation and Activity of Bone Cell Lineages.
Invest Radiol
July 2024
From the Bone and Joint Program, Department for BioMedical Research, University of Bern, Bern, Switzerland (F.S., W.H., R.J.E.); Graduate School for Cellular and Biomedical Sciences, University of Bern, Switzerland (F.S.); RMS-Foundation, Bettlach, Switzerland (C.S.); Department of Diagnostic, Interventional, and Pediatric Radiology, University Hospital, Inselspital, University of Bern, Bern, Switzerland (J.T.H., R.J.E.); and Clinic for Cranio-Maxillofacial Surgery, Department for BioMedical Research, University of Bern, Bern, Switzerland (W.H.).
Objectives: Administration of gadolinium-based contrast agents (GBCA) in magnetic resonance imaging results in the long-term retention of gadolinium (Gd) in tissues and organs, including the bone, and may affect their function and metabolism. This study aims to investigate the effects of Gd and GBCA on the proliferation/survival, differentiation, and function of bone cell lineages.
Materials And Methods: Primary murine osteoblasts (OB) and osteoclast progenitor cells (OPC) isolated from C57BL/6J mice were used to test the effects of Gd 3+ (12.
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