Organising pneumonia (OP) is a distinct clinicopathological entity resulting from pulmonary reaction to noxious environmental or endogenous factors, but also idiopathic cases have been noted. Frequently, small foci of OP accompany lung cancer infiltrations. Also OP is sometimes a reaction to radio- or chemotherapy, but it is rarely a predominant lesion in the course of lung cancer. We present the case of 65-year-old patient who presented with fever, dry cough, exertional dyspnoea and pneumonic consolidation in the right lower lobe. Bronchoscopy revealed squamous carcinoma obstructing the right lower bronchi. He was surgically treated, and the right lower lobe was resected. Pathological examination of a specimen revealed only small infiltration of carcinoma cells in the wall of the bronchi and large confluent areas of organising pneumonia. Surgery was a sufficient treatment for both diseases. Six months later he was in good condition without any pulmonary infiltrations. To sum up, a case of endobronchial squamous cell carcinoma in stage T1N0M0 with predominant clinical and radiological signs of OP is presented.
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BMC Pulm Med
December 2024
Medical Department I, Division of Pneumology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Purpose: The role of lung biopsy for evaluation of persistent chest radiographic abnormalities including secondary organizing pneumonia (OP) in COVID-19 remains uncertain. This study aimed to evaluate the diagnostic value of trans-bronchial forceps biopsy (TBFB) in patients with persistent lung abnormalities on thoracic computed tomography (CT) scan following SARS-CoV-2 infection with particular focus on cases with OP and immunocompromised (IC) patients.
Methods: Descriptive retrospective single center analysis of all TBFB performed for diffuse lung parenchymal changes after COVID-19 03-2020 to 06-2023.
Tanaffos
January 2024
Department of Pulmonary Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Background: Cryptogenic organizing pneumonia (COP) is a rare lung condition affecting the bronchioles and alveoli. This study aimed to determine the course of the disease and response to treatment in a group of COP patients.
Materials And Methods: In a cohort study, patients' data including demographic features, chest imaging, spirometry, and blood tests, were recorded.
Cureus
November 2024
Pulmonary and Critical Care Medicine Service, Brooke Army Medical Center, San Antonio, USA.
Organizing pneumonia (OP) directly caused by ongoing cigarette smoking does not appear to have been previously described. Despite OP having pathophysiological features distinct from lung cancer, the two may be confused based on similar clinical, radiological, and histopathological findings. This distinction is further clouded by the dynamic nature of these diseases.
View Article and Find Full Text PDFTransl Lung Cancer Res
November 2024
Internal Medicine III, Wakayama Medical University, Wakayama, Japan.
Background: Lung mucinous adenocarcinoma has various genetic alterations, but there are no reported cases with exon 14 skipping mutations. Multiplex genetic testing is commonly assessed in non-small cell lung cancer (NSCLC) and treatment usually comprises molecular targeted drugs. However, the efficacy of molecular targeted drugs in lung mucinous adenocarcinoma is not reported.
View Article and Find Full Text PDFJ Thorac Imaging
December 2024
Department of Radiology, New York University - Langone Health, New York, NY.
Acute lung injury (ALI) is acute pulmonary inflammation with underlying pathology of disruption of the pulmonary vasculature endothelial and alveolar epithelial barriers. ALI is not an uncommon diagnosis and has a myriad of causes including pulmonary infection, (including sepsis), drugs, connective tissue disease, and polytrauma. Patients present clinically with hypoxemia with imaging supportive of bilateral pulmonary findings without pulmonary edema.
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