Topology-Bayes versus Clade-Bayes in phylogenetic analysis.

Mol Biol Evol

Division of Invertebrate Zoology, American Museum of Natural History, NY, USA.

Published: February 2008

AI Article Synopsis

  • The text discusses features of Bayesian methods used in phylogenetic analysis, highlighting the differences between Clade-Bayes and Topology-Bayes.
  • It presents an empirical example to illustrate these distinctions.
  • It identifies three main problems with Clade-based Bayesian methods—exaggerated clade support, biased priors, and difficulty in hypothesis testing—arguing that Topology-based methods avoid these issues.

Article Abstract

Several features of currently used Bayesian methods in phylogenetic analysis are discussed. The distinction between Clade-Bayes and Topology-Bayes is presented and illustrated with an empirical example. Three problems with Bayesian phylogenetic methods--exaggerated clade support, inconsistently biased priors, and the impossibility of hypothesis testing of cladograms--are shown to be the result of using a Clade-based Bayesian approach. Topology-based Bayesian methods do not share these shortcomings.

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Source
http://dx.doi.org/10.1093/molbev/msm274DOI Listing

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