AI Article Synopsis

  • The study explored the connections between the retina and raphe nuclei in monkeys using cholera toxin B subunit injections.
  • Positive fibers were found in the dorsal raphe nucleus on the opposite side of the injection, with a few labeled cell bodies detected on the same side.
  • The findings suggest that these connections could play a role in how light and dark cycles affect the activity of raphe neurons and possibly influence various neural and behavioral systems.

Article Abstract

Possible connections between the retina and the raphe nuclei were investigated in the monkey Cebus apella by intraocular injection of cholera toxin B subunit (CTb). CTb-positive fibers were seen in the lateral region of the dorsal raphe nucleus (DR) on the side contralateral to the injection, and a few labeled perikarya were observed in the lateral portion of the DR on the ipsilateral side. Our findings suggest that direct and reciprocal connections between the retina and DR may exist in Cebus apella. These connections might be part of an important pathway through which the light/dark cycle influences the activity and/or functional status of raphe neurons, with potential effects on a broad set of neural and behavioral circuits.

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http://dx.doi.org/10.1016/j.neulet.2007.10.032DOI Listing

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