AI Article Synopsis
- Whipple's disease is a recurring infectious condition likely caused by the bacteria Tropheryma whippelii, diagnosed through specific tissue features and PCR testing.
- A case study of a 23-year-old woman highlights symptoms such as encephalopathy, neuropathy, high fever, and hormonal imbalance, leading to amenorrhea.
- The discussion suggests that her hormonal issues may result from either prolonged high fever damaging ovarian function or the presence of the bacteria in ovarian tissue.
Article Abstract
Introduction: Whipple's disease is a relapsing systemic infectious disease probably caused by the Gram-positive bacillus Tropheryma whippelii. The diagnosis can be established based on the characteristic histopathological features found in the affected organ (foamy macrophages with a coarsely granular cytoplasm, which stains with PAS, and by means of polymerase chain reaction (PCR) technology).
Case Report: We report a case of a 23-year-old woman affected by suspected Whipple's disease. She presented encephalopathy and neuropathy with inveterate hyperpyrexia and alteration of the hypothalamic-pituitary-ovary axe. She was amenorrheic because of an hypergonadotropic hypogonadism.
Discussion: This hypogonadism is possibly due to follicular depletion caused by inveterate hyperpyrexia or T. whipplii localization.
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| http://dx.doi.org/10.1016/j.fertnstert.2007.01.121 | DOI Listing |
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