AI Article Synopsis
- The study aimed to determine the frequency and prognostic importance of a basal phenotype in women with small, screen-detected invasive breast cancer.
- Approximately 12% of the participants had a basal immunophenotype, and those with this phenotype had higher breast cancer mortality rates compared to their non-basal counterparts.
- Basal phenotype emerged as a significant independent prognostic factor, especially in women with tumors smaller than 15 mm.
Article Abstract
Objective: To assess the frequency and prognostic significance of a basal phenotype in a group of women with screen-detected invasive breast cancers with long-term follow-up and to focus particularly on women with small ( < 15 mm) breast cancers.
Methods: The study group was derived by finding women common to a consecutive series of 1944 invasive breast cancers diagnosed in Nottingham between 1986 and 1998 with a known basal phenotype status and a prospectively collected database of all screen-detected breast cancers. In total, 356 women constituted the study group. Pathological and radiological features were recorded. Basal cell markers used were CK5/6 (cloneD5/16134) and CK14 (clone LL002). Tumours were classified as of basal phenotype if > or = 10% staining was seen with either marker.
Results: Of all screen-detected lesions, 43 (12%) had a basal immunophenotype and 313 (88%) were non-basal. There were 15 (35%) and 40 (13%) breast cancer deaths in the basal group and nonbasal groups, respectively ( P = 0.0006). On univariate analysis, nodal stage, histological grade, lympho-vascular invasion (LVI) status, invasive size and basal phenotype had prognostic significance. On multivariate analysis, basal phenotype, LVI and nodal stage maintain prognostic significance. Of the 189 women with < 15 mm lesions, eight of 20 (40%) of the basal group and eight of 169 (5%) of the non-basal group died of breast cancer ( P < 0.0001). On multivariate analysis, basal phenotype was the only factor to maintain independent prognostic significance.
Conclusions: Basal phenotype is a powerful prognostic factor for women with small screen-detected invasive breast cancer.
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| http://dx.doi.org/10.1258/096914107782912004 | DOI Listing |
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