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Maize Streak Virus: Single and Gemini Capsid Architecture.
Viruses
November 2024
Department of Biochemistry and Molecular Biology, College of Medicine Center for Structural Biology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610-0245, USA.
are ssDNA plant viruses whose control has both economical and agricultural importance. Their capsids assemble into two distinct architectural forms: (i) a T = 1 icosahedral and (ii) a unique twinned quasi-isometric capsid. Described here are the high-resolution structures of both forms of the maize streak virus using cryo-EM.
View Article and Find Full Text PDFPolycystic Ovary Syndrome and the Potential for Nanomaterial-Based Drug Delivery in Therapy of This Disease.
Pharmaceutics
December 2024
School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming 650500, China.
Polycystic ovary syndrome (PCOS) is the predominant endocrine disorder among women of reproductive age and represents the leading cause of anovulatory infertility, which imposes a considerable health and economic burden. Currently, medications used to treat PCOS can lead to certain adverse reactions, such as affecting fertility and increasing the risk of venous thrombosis. Drug delivery systems utilizing nanomaterials, characterized by prolonged half-life, precision-targeted delivery, enhanced bioavailability, and reduced toxicity, are currently being employed in the management of PCOS.
View Article and Find Full Text PDFDietary Patterns, Serum BDNF and Fatty Acid Profiles in Physically Active Male Young Adults: A Cluster Analysis Study.
Nutrients
December 2024
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland.
Although physical activity and balanced diet may increase peripheral brain-derived neurotrophic factor (BDNF) concentration, little is known about whether these factors modify BDNF content in physically active individuals and whether the serum fatty acid (FA) profile is related. This study aimed to evaluate quality of diet, identify specific dietary patterns and assess their influence on BDNF and FA levels in serum. It is hypothesized that there is a correlation between diet quality and the concentrations of BDNF and FA in the serum of physically active male individuals.
View Article and Find Full Text PDFExploring the Connections Between Grip Strength, Nutritional Status, Frailty, Depression, and Cognition as Initial Assessment Tools in Geriatric Rehabilitation-A Pilot Study.
Medicina (Kaunas)
November 2024
Doctoral School, University of Medicine and Pharmacy Carol Davila, Dionisie Lupu Street, No. 37, Sector 2, 020021 Bucharest, Romania.
In the context of the rapidly aging global population, the older adult vulnerability poses a significant challenge for public health systems. Frailty, cognitive and nutritional status, depression, and grip strength are essential parameters for staging the vulnerability of older adults. The objective of this study is to identify a rapid but multidimensional geriatric assessment tool that can enhance the rehabilitation process for older adults, tailored to their specific needs.
View Article and Find Full Text PDFDynamic Focus on Tumor Boundaries: A Lightweight U-Net for MRI Brain Tumor Segmentation.
Bioengineering (Basel)
December 2024
Department of Computer Engineering, Gachon University Sujeong-Gu, Seongnam-si 13120, Gyeonggi-Do, Republic of Korea.
Accurate segmentation of brain tumors in MRI scans is critical for diagnosis and treatment planning. Traditional segmentation models, such as U-Net, excel in capturing spatial information but often struggle with complex tumor boundaries and subtle variations in image contrast. These limitations can lead to inconsistencies in identifying critical regions, impacting the accuracy of clinical outcomes.
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