AI Article Synopsis
- The study aimed to examine the link between C-Reactive Protein (hsCRP) levels, a marker of inflammation, and endothelial dysfunction in patients suffering from intermittent claudication.
- Researchers conducted a cross-sectional study with 156 patients, measuring their flow-mediated arterial dilation (FMAD) and levels of hsCRP and fibrinogen, while considering various health factors like age, gender, and medical history.
- Results showed that patients with reduced FMAD (under 3%) had significantly higher levels of hsCRP and fibrinogen, and a negative correlation was found between hsCRP and FMAD, suggesting that inflammation may contribute to endothelial dysfunction and peripheral arterial disease.
Article Abstract
Objectives: To evaluate the relationship between C-Reactive Protein (hsCRP), a serum marker of inflammation, and endothelial dysfunction in patients with intermittent claudication.
Design, Patients And Methods: Cross-sectional study with stratified sampling on dependent variables of age, genre, hypertension, hyperlipidemia, diabetes, smoking status and ankle-brachial index (ABI) to select 156 patients from a target population of 4,100 patients with claudication. We assessed the flow-mediated arterial dilation (FMAD) as a reporter of endothelial function and plasma levels of hsCRP and fibrinogen.
Results: Patients with a FMAD<3% (range for the lowest 5% of healthy subjects) had increased levels of plasma hsCRP (6.3 vs 2.3mg/L; p<0.05) and fibrinogen (351vs 302mg/L; p<0.05) in comparison to those with FMAD>3%. There was a negative correlation between hsCRP and FMAD(r=-0.465; p<0.05).
Conclusion: Impaired endothelial dysfunction is association with increased plasma concentrations of inflammatory markers, and both may have a role in the aetiopathogenesis of peripheral arterial disease.
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| http://dx.doi.org/10.1016/j.ejvs.2007.10.016 | DOI Listing |
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