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Treatment of Intracranial Infection by Extensively Drug-Resistant Acinetobacter Baumannii After Craniocerebral Surgery.
J Craniofac Surg
October 2024
Department of Critical Care Medicine, Yangtze River Shipping, General Hospital/Wuhan Brain Hospital, Wuhan, Hubei.
Objective: The clinical outcome of intracranial infections caused by extensively drug-resistant Acinetobacter baumannii (XDRAB) remains unsatisfactory, even when treated with combined antibiotic therapy. This study successfully cured 1 patient with XDRAB intracranial infection after cranial surgery through a multichannel combination of drugs, providing a reference for the clinical treatment of severe XDRAB intracranial infection.
Methods: The clinical data of a patient with an XDRAB intracranial infection after a craniocerebral operation were retrospectively analyzed, and the treatment approach for XDRAB intracranial infection was examined.
Clinical and microbiological characteristics of carbapenem-resistant Enterobacteriaceae causing post-operative central nervous system infections in China.
J Glob Antimicrob Resist
December 2023
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Infection Control Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:
Objectives: Postoperative central nervous system infections (PCNSIs) caused by carbapenem-resistant Enterobacteriaceae (CRE) frequently result in unfavourable outcomes. However, CRE PCNSIs have not been well described from a clinical and microbiological perspective.
Methods: A total of 254 PCNSIs cases were included (January 2017 through June 2020), and clinical features were compared based on pathogenic classification.
Lumbar Cistern Drainage and Gentamicin Intrathecal Injection in the Treatment of Carbapenem-Resistant Klebsiella Pneumoniae Intracranial Infection After Intracerebral Hemorrhage craniotomy: A Case Report.
Infect Drug Resist
November 2022
The Second affiliated Hospital, Department of Neurosurgery, Hengyang Medical School, University of South China, Hengyang, 421001, People's Republic of China.
Background: Intracranial infection is a common complication caused by craniotomy. In particular, patients in Intensive Care Units (ICU) are prone to intracranial infection with multiple drug-resistant bacteria. Due to the lack of sensitive antibiotics for the treatment of multiple drug-resistant bacteria, there are few literatures focusing on the treatment of intracranial infection, and patients often fail to receive unified and standardized treatment.
View Article and Find Full Text PDFAutologous Free Fascia Lata Can Be Used as Dura Graft in the Salvage Treatment of Recalcitrant Postcraniotomy Intracranial Infection Caused by Multidrug-Resistant Gram-Negative Bacteria.
Infect Drug Resist
September 2022
Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Objective: The multidrug-resistant (MDR) gram-negative bacteria-induced intracranial infections after neurosurgical procedures represent a particular therapeutic challenge. Combining the removal of infected prosthetic meninge plus an appropriate antibiotic administration appears to be the only therapeutic strategy likely to succeed when the infection is complicated by artificial dura mater. This study aimed to assess the efficacy of free fascia lata as a substitute for dura reconstruction in the salvage treatment for such recalcitrant nosocomial infections.
View Article and Find Full Text PDFSuccessful Treatment of Severe Post-craniotomy Meningitis Caused by an Sequence Type 410 Strain Coharboring and .
Front Microbiol
September 2021
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Intracranial infections caused by multidrug-resistant Gram-negative bacterium have led to considerable mortality due to extremely limited treatment options. Herein, we firstly reported a clinical carbapenem-resistant isolate coharboring and from a patient with post-craniotomy meningitis. The carbapenem-resistant strain CNEC001 belonging to Sequence Type 410 was only susceptible to amikacin and tigecycline, both of which have poor penetration through the blood-brain barrier (BBB).
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