A new cationic polyhydroxylated lipid, characterized by a chiral template, was synthesized. It comes from an iridoid glucoside, as polyhydroxylated moiety. This lipid affords liposomes using cholesterol-like co-lipid. The liposomes had a spheroidal shape with a small size distribution.
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http://dx.doi.org/10.1080/14786410500162526 | DOI Listing |
Nano Lett
December 2024
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China.
Topochemical reactions normally occurring in the solid and crystalline state exhibit solvent-free and catalyst-free properties, with high atom economy properties, which have been widely applied in materials science and polymer synthesis. Herein, we explore the potential of topochemical reactions for controlling the emergence of supramolecular chirality and the precise fabrication of chiroptical materials. Boronic acid pinacol esters (BPin) were conjugated to naphthalimides containing an inherent chiral cholesteryl group linked by alkyl or benzene spacers.
View Article and Find Full Text PDFPolymers (Basel)
September 2024
Division of Functional Polymers and Polymer Materials, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, H. Sienkiewicza 112, 90-363 Lodz, Poland.
Many therapies require the transport of therapeutic compounds or substances encapsulated in carriers that reduce or, if possible, eliminate their direct contact with healthy tissue and components of the immune system, which may react to them as something foreign and dangerous to the patient's body. To date, inorganic nanoparticles, solid lipids, micelles and micellar aggregates, liposomes, polymeric micelles, and other polymer assemblies were tested as drug carriers. Specifically, using polymers creates a variety of options to prepare nanocarriers tailored to the chosen needs.
View Article and Find Full Text PDFInt J Nanomedicine
August 2024
Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University; Luzhou, Sichuan, 646000, People's Republic of China.
Purpose: The present study aimed to develop a lipid nanoplatform, denoted as "BAL-PTX-LN", co-loaded with chiral baicalin derivatives (BAL) and paclitaxel (PTX) to promote the anti-lung cancer efficacy of paclitaxel and reduce the toxicity of chemotherapeutic drugs.
Methods: BAL-PTX-LN was optimized through central composite design based on a single-factor experiments. BAL-PTX-LN was evaluated by TEM, particle size, encapsulation efficiency, hemolysis rate, release kinetics and stability.
J Colloid Interface Sci
November 2024
State Key Laboratory of Heavy Oil Processing, College of Chemistry and Chemical Engineering, China University of Petroleum, Qingdao 266580, China. Electronic address:
Sphingosine, an amphiphilic molecule, plays a pivotal role as the core structure of sphingolipids, essential constituents of cell membranes. Its unique capability to enhance the permeability of lipid membranes profoundly influences crucial life processes. The molecular structure of sphingosine dictates its mode of entry into lipid bilayers and governs its interactions with lipids, thereby determining membrane permeability.
View Article and Find Full Text PDFInt J Nanomedicine
June 2024
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, 563000, People's Republic of China.
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