Objective: To explore the pharmacodyniamic action and the mechanism of action of the Maxingganshi decoction in acute lung injury rats in order to supply the pharmacology evidence to cure the SIRS-ALI of Maxingganshi decoction.
Methods: The study designed by orthogonal design. The SIRS-ALI model were Conseructed by the LPS intravenous injection and the effects of Maxingganshi decoction and it's different compatibilities to the SIRS-ALI model were observed. The experiments results were analvsised in order to reveal the compatibility rules of the Maxingganshi decocotion.
Results: Maxingganshi decocotion and its different compatibilities had good effects of prevention and cure the SIRS-ALI. The mechanism maybe concerned with the Maxingganshi decocotion can decrease the TNF-alpha and increase the IL-10. The experiments results also indicated that the action of the full formula was the best. The principal drug was the most important in the formula.
Conclusion: Maxingganshitang has a good effect in anti the ALI; the results indicat that the principal drug is the predominant therapeutic action in the formula ministerial drug. Adjuvant drug and messenger drug can strengthen pharmacodynamic action.
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View Article and Find Full Text PDF[The empirical study of Maxingganshi decoction and its compatibility in acute lung injury rats].
Zhong Yao Cai
August 2007
Guangdong Provincial Health Care Hospital for Women and Children, Guangzhou 510010, China.
Objective: To explore the pharmacodyniamic action and the mechanism of action of the Maxingganshi decoction in acute lung injury rats in order to supply the pharmacology evidence to cure the SIRS-ALI of Maxingganshi decoction.
Methods: The study designed by orthogonal design. The SIRS-ALI model were Conseructed by the LPS intravenous injection and the effects of Maxingganshi decoction and it's different compatibilities to the SIRS-ALI model were observed.
[Influence of compatibility on content of berberine in Maxingganshi decoction].
Zhong Yao Cai
May 2007
Guangdong Provincial Health Care Hospital for Women and Children, Guangzhou 510010, China.
Article Synopsis
- The study aimed to establish a method for measuring herberine levels in different Maxingganshi decoction combinations using HPLC and evaluate how these combinations affect overall content.
- By using a specific experimental design, researchers found that removing certain ingredients (Glycyrrhiza uralensis and armeniacae semen) significantly altered the levels of various compounds, such as L-ephedrine and glycyrrhetic acid.
- The results indicate that armeniacae semen reduces L-ephedrine and D-pseudephedrine levels, while Glycyrrhiza uralensis enhances the extraction of useful compounds like amygdaloside and glycyrrhizic acid.
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