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Background: Occurrence of life-threatening scorpion sting in adults is a rare entity compared with children. Different cases of organ failure following scorpion sting have been reported but complications, such as acute toxic myocarditis, cardiogenic shock, pulmonary edema, acute kidney injury and toxic hepatitis occurring simultaneously in adult patients is exceedingly rare with no prior documented similar report. This case report explores the unique presentation of these complications occurring simultaneously and their management in resource limited setting.
View Article and Find Full Text PDFCritical heart failure associated with beta-blocker-induced cardiac phospholipidosis: a case report.
Eur Heart J Case Rep
December 2024
Department of Cardiology, Tokyo Metropolitan Police Hospital, 4-22-1 Nakano, Nakano, Tokyo 164-8541, Japan.
Background: Drug-induced phospholipidosis (DIPL) is an acquired lysosomal storage disorder characterized by the accumulation of lamellar bodies and phospholipids, typically associated with the use of cationic amphiphilic drugs (CADs). Over 200 marketed CADs, including widely prescribed β-blockers, have the potential to induce phospholipid deposition in various organs. In rare cases, DIPL may lead to secondary cardiomyopathy.
View Article and Find Full Text PDFReversible Dilated Cardiomyopathy in a Male Patient With Rheumatoid Arthritis: A Case Report.
Cureus
October 2024
Rheumatology, Orlando College of Osteopathic Medicine, Orlando, USA.
Article Synopsis
- * The patient experienced symptoms like shortness of breath and palpitations, leading to a diagnosis of congestive heart failure and severe heart function reduction, with no signs of coronary artery disease found.
- * After discontinuing the medications, the patient's heart function improved over time, indicating the importance of monitoring heart health in patients with chronic inflammatory diseases and the careful evaluation of treatment risks by physicians.
Pancytopenia, Cholestatic Jaundice, and Pulmonary Hypertension: Rare Extrathyroidal Manifestations of Graves' Disease.
Cureus
October 2024
Endocrinology, Hospital Sultanah Aminah, Johor Bahru, MYS.
Pancytopenia, cholestatic jaundice, and pulmonary hypertension are rare but serious complications of thyrotoxicosis. It is uncommonly seen in patients with hyperthyroidism and may result in treatment-related dilemmas as bone marrow suppression and drug-induced liver injury are known complications of anti-thyroid treatment. We describe a case of Graves' disease presenting with all three manifestations of pancytopenia, cholestatic jaundice, and pulmonary hypertension during a relapse of thyrotoxicosis.
View Article and Find Full Text PDFPeroxisome proliferator‑activated receptor γ coactivator‑1α in heart disease (Review).
Mol Med Rep
January 2025
Department of Cardiology, Life Science Center, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China.
Article Synopsis
- Heart disease (HD) encompasses various heart-related diseases, and research indicates that mitochondrial dysfunction plays a key role in its development.
- The protein PGC‑1α is crucial for maintaining mitochondrial function by influencing energy metabolism, biogenesis, and response to oxidative stress, and its activity is modulated by multiple signaling pathways.
- The review also discusses the involvement of PGC‑1α in several HD conditions, such as heart failure and diabetic cardiomyopathy, highlighting the complexity of its therapeutic role and the challenges in targeting it for treatment.
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