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Gut Microbial Signatures Associated with Cryptosporidiosis: A Case Series.
Microorganisms
February 2025
Unit of Microbiology and Diagnostic Immunology, Unit of Microbiomics and Management and Diagnostic Innovations & Clinical Pathways Research Area, Unit of Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy.
spp. are zoonotic protozoan parasites with a global prevalence, with both gastrointestinal and pulmonary involvement. Though symptoms can often be relatively mild, they can become severe and even fatal in children under five, the elderly, and in immunocompromised individuals, making cryptosporidiosis a leading cause of morbidity and mortality in fragile populations.
View Article and Find Full Text PDFLiver parasites: A global endemic and journey from infestation to intervention.
World J Gastroenterol
January 2025
Department of Medicine, Section of Gastroenterology, Aga Khan University Hospital, Karachi 75500, Sindh, Pakistan.
Parasites have coexisted with humans throughout history, forming either symbiotic relationships or causing significant morbidity and mortality. The liver is particularly vulnerable to parasitic infections, which can reside in, pass through, or be transported to the liver, leading to severe damage. This editorial explores various parasites that infect the liver, their clinical implications, and diagnostic considerations, as discussed in the article "Parasites of the liver: A global problem?".
View Article and Find Full Text PDFA rare case of pulmonary cryptosporidiosis associated with pulmonary tuberculosis in a patient with advanced HIV infection.
Parasitol Int
February 2025
Clinical Hospital of Infectious Diseases of Cluj-Napoca, 23 Iuliu Moldovan, 400348 Cluj-Napoca, Romania; Department of Infectious Diseases and Epidemiology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 23 Iuliu Moldovan, 400348 Cluj-Napoca, Romania.
Cryptosporidium spp., an important food and waterborne protozoan pathogen, can cause severe diarrhea and extraintestinal manifestations in immunocompromised individuals. The case of a 75 -years old patient diagnosed as a late presenter with advanced HIV infection and multiple opportunistic illnesses associated to HIV: cryptosporidiosis, intestinal and pulmonary, Cytomegalovirus colitis and pulmonary tuberculosis is presented.
View Article and Find Full Text PDFProdrug nanotherapy demonstrates anticryptosporidial efficacy in a mouse model of chronic infection.
RSC Pharm
December 2024
Department of Pharmacology, Yale University School of Medicine 333 Cedar Street New Haven CT 06520 USA +1 (203) 785-4526.
The gastrointestinal disease cryptosporidiosis, caused by the genus , is a common cause of diarrheal diseases in children, particularly in developing countries and frequently fatal in immunocompromised individuals. ()-specific bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) has been a molecular target for inhibitor design. (.
View Article and Find Full Text PDFFeatures of cryptococcosis among 652 HIV-seronegative individuals in France: a cross-sectional observational study (2005-2020).
Clin Microbiol Infect
July 2024
Université Paris Cité, Department of Infectious Diseases and Tropical Medicine, Necker - Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), IHU Imagine, 75014 Paris, France; Mycology Department, Institut Pasteur, Université Paris Cité, National Reference Center for Invasive Mycoses and Antifungals, Mycology Translational Research Group, France.
Objectives: We aimed to describe features and outcomes of cryptococcosis among HIV-seronegative individuals in a large surveillance network for cryptococcosis in France.
Methods: We included incident cases of cryptococcosis in HIV-seronegative individuals from 2005 to 2020. We compared patient characteristics, disease presentations, cryptococcal antigen results, and induction antifungal treatments according to underlying disease.
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