Although alcoholics and individuals at risk for alcoholism often show smaller amplitude of the P3 event-related brain potential (ERP), recent data (K. Namkoong, E. Lee, C. H. Lee, B. O. Lee, & S. K. An, 2004) indicate that alcohol-related cues elicit larger P3 amplitude in alcoholics than in controls. Little is known concerning the ERP profiles or alcohol cue reactivity of social drinkers at risk for alcoholism due to low sensitivity to alcohol's effects. Participants differing in alcohol sensitivity viewed images of alcoholic and nonalcoholic beverages while ERPs were recorded and provided information about their alcohol use patterns at baseline and 4 months later. Compared to high-sensitivity participants, those low in sensitivity showed larger P3s to alcohol cues, even when recent alcohol use was statistically controlled for. Moreover, the P3 elicited by alcohol cues predicted alcohol use at follow-up, a finding supporting the idea that P3 amplitude reflects the motivational significance of substance-related cues. These findings point to risk status, not consumption history, as an important predictor of cue reactivity effects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1037/0893-164X.21.4.555 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [F]fallypride positron emission tomography.
Alcohol Clin Exp Res (Hoboken)
December 2024
Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada.
Background: Adolescent alcohol use is the norm, but only some develop a substance use disorder. The increased risk might reflect heightened mesocorticolimbic responses to reward-related cues but results published to date have been inconsistent.
Methods: Young social drinkers (age 18.
New therapeutic approaches for alcohol dependence (AD) include virtual reality (VR)-based treatments offering scalable options for cue exposure (CE), a well-established strategy in cognitive behavioral therapy. This study aimed to evaluate the feasibility and tolerability of a new VR-CE paradigm. On an explorative basis, factors influencing the induction of craving were examined.
View Article and Find Full Text PDFContrasting Responses to Ethenylbenzene (Styrene) and 2-Ethyl-1-hexanol Suggest their Role as Chemical Cues in Host Selection by the Seed Beetle Zabrotes subfasciatus (Coleoptera: Chrysomelidae: Bruchinae).
Neotrop Entomol
December 2024
Depto de Biologia Celular e Do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, UNIFAL-MG, Alfenas, Minas Gerais, Brazil.
Seed beetles spend most of their lives within the seeds of host plants belonging to the Fabaceae family. Evidence suggests the cues that mediate pre-oviposition behaviour in Zabrotes subfasciatus (Boheman) are volatile organic compounds (VOCs) emitted by the seeds and suggests differential abilities in environment sensing between sexes. Here, we tested whether VOCs from different legume species trigger different levels of attraction, whether females and males differ in their ability to respond to VOCs, and whether the seeds promoting different behaviours feature singular VOCs.
View Article and Find Full Text PDFA Randomized Controlled Trial of Medial Prefrontal Cortex Theta Burst Stimulation for Cocaine Use Disorder: A Three-Month Feasibility and Brain Target-Engagement Study.
Biol Psychiatry Cogn Neurosci Neuroimaging
December 2024
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC; Department of Neurosciences, Medical University of South Carolina, Charleston, SC; Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC.
Background: Cue-induced craving precipitates relapse in drug and alcohol use disorders. Theta burst stimulation (TBS) to the left frontal pole of the medial prefrontal cortex (MPFC) has previously been shown to reduce drinking and brain reactivity to alcohol cues. This randomized, double-blind, sham-controlled target-engagement study aimed to assess whether TBS has similar effects in individuals with cocaine use disorder (CUD).
View Article and Find Full Text PDFMen's influence of maternal substance use before, during, and after pregnancy: A qualitative study of men with criminal-legal involvement.
Drug Alcohol Depend
January 2025
Department of Occupational Science and Occupational Therapy, Doisy College of Health Sciences, Saint Louis University, 3437 Caroline St., Suite 2020, St. Louis, MO 63104, USA.
Background: While the adverse effects of substance use during pregnancy are well-established, the impact men with criminal-legal involvement who use substances have on their partner's substance-using behaviors is not well characterized. We aim to understand men's experiences and perspectives about how their substance use impacts romantic partner substance use in the preconception period, before a potential or actual pregnancy.
Methods: We conducted semi-structured interviews with men residing in a transition center in the Midwestern US with a substance use disorder (SUD) who partnered with women.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!