AI Article Synopsis
- The study investigated central and peripheral tolerance in relapsing-remitting multiple sclerosis patients, comparing those treated with IFN-beta to untreated individuals.
- TREC-positive T cells were found to be lower in patients, especially in the CD4+ subgroup, suggesting issues with thymus function or increased peripheral lymphocyte expansion.
- While IFN-beta treatment did not change TREC-positive cell counts or naive/memory T cell ratios, it was associated with lower overall blood lymphocyte counts and a decreased frequency of the CD4+CD45RC(high) subset.
Article Abstract
We explored the parameters of central and peripheral tolerance in patients with stable relapsing-remitting multiple sclerosis, treated or not with IFN-beta. TREC-positive T cells were lower in patients compared with controls, mainly in CD4+ subset, compatible with a thymus dysfunction or an expansion of peripheral lymphocytes. Compared to controls, the frequency of activated CD4+CD25+ T cells was higher in patients without modification of the CD4+CD25(high) T cell proportion. The IFN-beta-treatment did not modify the TREC-positive cell frequency nor the naive/memory T cell subset percentage but was associated with lower blood lymphocyte count and a lower frequency of CD4+CD45RC(high) subset.
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| http://dx.doi.org/10.1016/j.jneuroim.2007.10.027 | DOI Listing |
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