Priming from repeated distractor sets, or search context, in conjunctive visual search was examined in four patients with hemispatial neglect. In the first experiment overall context was either changed or repeated while the target was always the same to control for any modulatory effect of target priming. Considerable priming was seen from repeated context. In the second experiment the context was either repeated on the left side, on the right side, on both sides, or the context was new. Priming from repeated context was found to arise from the left visual field, as well as the right visual field, as well as when overall context was repeated. Brief masked displays were used in experiment 3, the results again showing strong priming from repeated overall context. The results of the three experiments suggest that visual grouping, or perceptual organization, of distractor sets is relatively intact in the affected hemifield of parietal neglect patients. Furthermore, repetition of context may even temporarily ameliorate neglect symptoms in search. These findings are consistent with claims that grouping is distinct from attentional processing and that it operates at lower levels of the perceptual hierarchy.
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http://dx.doi.org/10.1016/j.neuropsychologia.2007.10.020 | DOI Listing |
Front Immunol
January 2025
Department of Antibody Engineering, Leadartis SL, Tres Cantos, Madrid, Spain.
Sci Immunol
January 2025
Department of Integrative, Structural and Computational Biology, Scripps Research, La Jolla, CA, USA.
Vaccination strategies against HIV-1 aim to elicit broadly neutralizing antibodies (bnAbs) using prime-boost regimens with HIV envelope (Env) immunogens. Epitope mapping has shown that early antibody responses are directed to easily accessible nonneutralizing epitopes on Env instead of bnAb epitopes. Autologously neutralizing antibody responses appear upon boosting, once immunodominant epitopes are saturated.
View Article and Find Full Text PDFPLoS Genet
January 2025
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada.
The synaptonemal complex (SC) is a protein-rich structure essential for meiotic recombination and faithful chromosome segregation. Acting like a zipper to paired homologous chromosomes during early prophase I, the complex is a symmetrical structure where central elements are connected on two sides by the transverse filaments to the chromatin-anchoring lateral elements. Despite being found in most major eukaryotic taxa implying a deeply conserved evolutionary origin, several components of the complex exhibit unusually high rates of sequence turnover.
View Article and Find Full Text PDFInterference from a salient distractor is typically reduced when the appearance of the distractor follows either spatial or feature-based regularities. Although there is a growing body of literature on distractor location learning, the understanding of distractor feature learning remains limited. In the current study, we investigated distractor feature learning by using EEG measures.
View Article and Find Full Text PDFInfect Immun
January 2025
1Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.
The lack of effective adaptive immunity against leads to chronic or repeated infection and serious disease sequelae. Dendritic cells (DCs) are professional antigen-presenting cells that are crucial for the activation of T cells during infection. cDC1s and cDC2s are the two main DC subsets responsible for T cell priming, but little is known about how affects their ability to prime T cells.
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