Bisphosphonates and avascular necrosis of the mandible: case report and review of the literature.

J Plast Reconstr Aesthet Surg

Division of Plastic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Published: April 2008

Background: Avascular necrosis of the mandible or maxilla is being recognized with increasing frequency in patients who are being treated with bisphosphonates for metastatic cancers.

Methods And Results: A patient who was treated for avascular necrosis following treatment with bisphosphonates for multiple myeloma is presented.

Conclusion: Prophylactic and preventative measures should be instituted prior to commencing treatment with bisphosphonates to minimize the risk of developing avascular necrosis.

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http://dx.doi.org/10.1016/j.bjps.2006.06.017DOI Listing

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