AI Article Synopsis
- The study aimed to examine the link between the MTNR1A gene promoter polymorphism (rs2119882) and adolescent idiopathic scoliosis (AIS).
- Researchers analyzed data from 226 AIS patients and 277 control subjects, using PCR-RFLP for genotyping.
- The findings revealed no significant association between the MTNR1A gene polymorphism and the occurrence or severity of scoliosis in the AIS patients.
Article Abstract
Objective: To investigate whether the MTNR1A gene promotor polymorphism (rs2119882) are associated with the occurrence or curve severity of adolescent idiopathic scoliosis (AIS).
Methods: 226 AIS patients and 277 normal controls were recruited. The maximum Cobb angles were recorded in AIS patients. PCR-RFLP was used for the genotyping.
Results: The genotype and allele frequency distribution were comparable between AIS and normal control, the mean maximum Cobb angle of different genotypes of rs2119882 were similar with each other among AIS patients.
Conclusion: The MTNR1A gene promoter polymorphism was neither associated with the occurrence nor the curve severity of AIS.
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