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[The methylation locus and frequency pattern on p16 INK4a gene promoter CpG in epidermis of patients with psoriasis]. | LitMetric
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[The methylation locus and frequency pattern on p16 INK4a gene promoter CpG in epidermis of patients with psoriasis].

Min Chen Pan-gen Cui Xu Yao Yuan-hua Cao Juan-qin Gong An-sheng Li Zhi-qiang Chen

Zhonghua Yi Xue Yi Chuan Xue Za Zhi

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, 210042 PR China.

Published: December 2007

Objective: To investigate the CpG methylation locus and frequency pattern on p16 INK4a gene promoter in epidermis of p16 INK4a methylated patients with psoriasis vulgaris.

Methods: The DNA specimens were obtained from epidermal lesion of 50 plaque psoriatic patients. Methylation specific PCR and DNA sequencing were used to detect the frequency and locus of methylation in p16 INK4a gene promoter region.

Results: Approximately 50% CpG was methylated in p16 INK4a methylated patients, methylation was found in specifical locus of p16 INK4a gene promoter.

Conclusion: The distinct methylation pattern is showed on the p16 INK4a gene promoter region in patients with psoriasis.

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