AI Article Synopsis
- Carboplatin therapy can lead to renal failure, primarily caused by acute tubular necrosis, but this is typically reversible.
- Severe cases of acute renal failure that rapidly progress to end-stage renal disease from carboplatin are extremely rare.
- The authors present a case of renal failure linked to carboplatin treatment for nasopharyngeal carcinoma and explore the underlying mechanisms of chronic kidney damage.
Article Abstract
Renal failure secondary to carboplatin therapy is due to acute tubular necrosis and is usually reversible. However, acute renal failure with rapid progression to end-stage renal disease is an exceedingly rare complication of carboplatin therapy. The authors report a case of definitive renal failure secondary to carboplatin chemotherapy for a nasopharyngeal carcinoma. The mechanisms that give rise to the chronic nephropathy are discussed.
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| http://dx.doi.org/10.1080/08860220701643591 | DOI Listing |
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