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Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis.
Commun Med (Lond)
December 2024
Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Rostock University Medical Center, Rostock, Germany.
Background: Menopause driven decline in estrogen exposes women to risk of osteoporosis. Detection of early onset and silent progression are keys to prevent fractures and associated burdens.
Methods: In a discovery cohort of 120 postmenopausal women, we combined repeated quantitative pulse-echo ultrasonography of bone, assessment of grip strength and serum bone markers with mass-spectrometric analysis of exhaled metabolites to find breath volatile markers and quantitative cutoff levels for osteoporosis.
Biomechanical Analysis of Diffuse Idiopathic Skeletal Hyperostosis and Osteoporosis: Vertebral Fracture Risk Evaluation Using Finite Element Modeling with Clinical and Micro-CT Data in an Elderly Donor.
Biomedicines
October 2024
Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, 18057 Rostock, Germany.
Biomechanical analysis of spinal structures is crucial in the evaluation of injuries, the risk of fracture, and age-related changes. Osteoporotic vertebrae are very fragile and therefore constitute a serious risk, especially in the elderly. At present, clinically relevant decision making in fracture risk assessment is predicated upon finite element analysis (FEA), which utilizes high-resolution computed tomography (CT) scans from clinical practice alongside micro-CT scans from laboratory settings.
View Article and Find Full Text PDFAutomatic AI tool for opportunistic screening of vertebral compression fractures on chest frontal radiographs: A multicenter study.
Bone
February 2025
Department of Medical Imaging, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China. Electronic address:
Vertebral compression fractures (VCFs) are the most common type of osteoporotic fractures, yet they are often clinically silent and undiagnosed. Chest frontal radiographs (CFRs) are frequently used in clinical practice and a portion of VCFs can be detected through this technology. This study aimed to develop an automatic artificial intelligence (AI) tool using deep learning (DL) model for the opportunistic screening of VCFs from CFRs.
View Article and Find Full Text PDFBone infection evolution.
Injury
November 2024
Department of Chemical and Biological Engineering, Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA.
The present minireview aims to provide a context for imagination of the timespan for bone infection evolution from the origin of cellular bone tissue to modern orthopedic surgery. From a phylogenetic osteomyelitis-bracketing perspective, and due to the time of osteocyte origin, bacteria might have been able to infect the skeleton for approximately 400 million years. Thereby, bone infections happened simultaneously with central expansions of the immune system and development of terrestrial bone structure.
View Article and Find Full Text PDFSilent severe aortic regurgitation due to blunt chest trauma: ignore it at your peril-a case report.
Eur Heart J Case Rep
October 2024
Department of Cardiology, Lister Hospital, East & North Hertfordshire NHS Trust, Coreys Mill Lane, Stevenage SG1 4AB, UK.
Background: Blunt chest trauma (BCT) presenting to the emergency department is common and may cause life-threatening cardiac complications. Whilst complications causing haemodynamic instability are generally detected promptly, others may present late with long-term consequences. We describe a rare, serious complication of BCT presenting five years after a road traffic accident (RTA).
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