The authors present the case of a male patient who was diagnosed with juvenile glaucoma after an ophthalmologic examination. The patient had a previous diagnosis: hydrocephaly.
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Fluids Barriers CNS
January 2025
Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
Background: Cerebral autoregulation is a robust regulatory mechanism that stabilizes cerebral blood flow in response to reduced blood pressure, thereby preventing cerebral ischaemia. Scientists have long believed that cerebral autoregulation also stabilizes cerebral blood flow against increases in intracranial pressure, which is another component that determines cerebral perfusion pressure. However, this idea was inconsistent with the complex pathogenesis of normal pressure hydrocephalus, which includes components of chronic cerebral ischaemia due to mild increases in intracranial pressure.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
November 2024
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Purpose: Optic nerve head (ONH) atrophy is frequently associated with hydrocephalic conditions. Cerebrospinal fluid (CSF)-containing meninges form a subarachnoid space that terminates at the ONH, which physically impacts it. This study aims to characterize optic neuropathy in congenital hydrocephalic mice with genetic disruption of the Ccdc13 gene.
View Article and Find Full Text PDFFront Genet
August 2024
Department of Basic Medical Sciences, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Background: α-mannosidosis (MAN) is a rare genetic condition that segregates in an autosomal recessive manner. Lack of lysosomal alpha-mannosidase is the underlying cause of the disease. Symptoms of the disease gradually worsen with the age.
View Article and Find Full Text PDFNeurol India
May 2024
Neuro-Ophthalmology Clinic & Glaucoma Service, AG Eye Hospital, Trichirapalli, Tamil Nadu, India.
Fluids Barriers CNS
July 2024
Neurosurgery of NeuroCenter, Unit of Neurosurgery, Institute of Clinical Medicine, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland.
Background: Idiopathic Normal Pressure Hydrocephalus (iNPH) is a chronic condition affecting the elderly. It is characterized by a triad of symptoms and radiological findings. Glaucoma is the leading cause of irreversible blindness worldwide.
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