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Transcriptome sequencing on different ages of Saraca asoca bark: Insights from tannin biosynthetic pathways and EST-SSR marker design.
Fitoterapia
February 2025
Institute of Forest Genetics and Tree Breeding (IFGTB), Coimbatore, 641 002, India. Electronic address:
The bark of Saraca asoca is extensively used for treating gynecological issues, primarily due to its tannin content. This study focused on transcriptome sequencing of young (BY; 0-6 years), middle-aged (BM; 6-12 years), and old (BO; >12 years) Ashoka barks. The de novo assembly produced 1,37,451 unigenes of 1,31,647,800 bp from BY, 1,16,825 unigenes of 1,15,283,571 bp from BM, and 81,825 unigenes of 68,553,092 bp from BO samples.
View Article and Find Full Text PDFThe New CMS Measure of Excessive Radiation Dose or Inadequate Image Quality in CT: Issues and Ambiguities-Perspectives from an AAPM-Commissioned Panel.
AJR Am J Roentgenol
February 2025
Reed and Martha Rice Distinguished Professor of Radiology, Medical Physics, Biomedical Engineering, Physics, and Electrical and Computer Engineering, Duke Health and Duke University, 2424 Erwin Road, Hock Plaza (Suite 302), Durham, NC 27705.
CMS has adopted a new CT quality measure seeking to discourage excessive radiation dose while preserving image quality. The measure score is expressed as the percentage of qualifying studies that exceed predetermined thresholds indicating inadequate image quality (based on image noise) or excessive radiation dose. The measure has been incorporated into the major CMS quality-based payment programs, impacting hospitals and clinician payments; measure reporting began in January 2025.
View Article and Find Full Text PDFPhase-resolved Functional Lung MRI Reveals Distinct Lung Perfusion Phenotype in Children and Adolescents with Post-COVID-19 Condition.
Radiology
February 2025
From the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).
Background Although measurable organic dysfunctions are frequently absent in pediatric patients with post-COVID-19 condition (PCC), this condition adversely affects quality of life. Free-breathing phase-resolved functional lung (PREFUL) MRI may be useful for assessing lung function in pediatric patients with PCC. Purpose To detect lung changes in children and adolescents with PCC compared with healthy control participants using PREFUL MRI.
View Article and Find Full Text PDFTo mark the 30th anniversary of The American Journal of Managed Care (AJMC), each issue in 2025 includes reflections from a thought leader on what has changed over the past 3 decades and what's next for managed care. The February issue features a retrospective by Richard J. Gilfillan, MD, former director of the Center for Medicare and Medicaid Innovation; and Donald M.
View Article and Find Full Text PDFBiomimetic Sealing of Cisplatin by Cancer Cell Membranes to Achieve Nucleophile Resistance and Tumor Targeting for Improved Cancer Therapy.
ACS Appl Mater Interfaces
February 2025
Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P.R. China.
Platinum-based anticancer drugs (PBCs), particularly cisplatin, play a key role in over 70% of cancer treatment protocols. PBCs suffer from their strong affinity with numerous nucleophiles present in the body, leading to significant systematic toxicity and rapid drug inactivation. The cell membrane's selective and energy-dependent transport properties, inherent to its unique biological structure, offer a strategic opportunity for employing cell membranes (CMs) in the development of PBC delivery systems that repel nucleophiles.
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